Influence of maternal consumption of different types of fatty acids during pregnancy and lactation on lipid and glucose metabolism of the 21-day-old male offspring in rats

Autor(es)

Mennitti, Lais Vales ^[1] ; Oyama, Lila Missae ^[2] ; Santamarina, Aline Boveto ^[1] ; do Nascimento, Oller ^[2] ; Pisani, Luciana Pellegrini ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Programa Pasgrad Interdisciplinar Ciencias Saude, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, Rua Botucatu 862, 2 Andar, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Inst Saude & Soc, Dept Biociencias, Rua Silva Jardim 136, Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS; v. 135, p. 54-62, AUG 2018.
• Citações Web of Science: 1

Resumo

We evaluated the impacts of maternal consumption of different types of fatty acids during pregnancy and lactation on the lipid and glucose metabolism of 21-day-old offspring. Rats received either control (C), saturated (SFAs), trans (TFAs) or n - 3 polyunsaturated (PUFAs) normolipidic diets throughout pregnancy and lactation. 21-day old male pups constituted the groups: C21, S21, T21 and PUFA21. At 21st day, serum parameters, hepatic triacylglycerol (TAG) deposition, oral glucose tolerance test (OGTT) and liver protein expressions were investigated. We found a decrease in serum concentrations of TAG, total cholesterol and FFA as well as in hepatic TAG content and baseline glycaemia, accompanied by an increase in catalase expression in PUFA21 group. In T21 group, OGTT showed slight disturbance in glucose homeostasis. Summarily, while early exposure to TFAs-based diets seems to harm pups' glucose homeostasis, maternal consumption of n - 3 PUFAs can improve lipid metabolism, TAG hepatic accumulation and catalase protein expression in 21-day-old offspring. (AU)

• Processo FAPESP: 14/10683-0 - Efeito da ingestão materna de diferentes ácidos graxos durante a gestação e lactação nas modificações epigenéticas e estado pró-inflamatório do feto e prole com 21 dias de vida
• Beneficiário: Laís Vales Mennitti
• Modalidade de apoio: Bolsas no Brasil - Doutorado