Dispersion of Lutzomyia longipalpis and expansion of visceral leishmaniasis in Sao Paulo State, Brazil: identification of associated factors through survival analysis

Autor(es)

Oliveira, Agda M. ^[1] ; Lopez, Rossana V. M. ^[2] ; Dibo, Margareth R. ^[3] ; Rodas, Lilian A. C. ^[4] ; Guirado, Marluci M. ^[5] ; Chiaravalloti-Neto, Francisco ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP - Brazil

^[2] Inst Canc Estado Sao Paulo, Ctr Translat Res Oncol, Sao Paulo, SP - Brazil

^[3] Superintendencia Controle Endemias Estado Sao Paul, Lab Biochem & Mol Biol, Sao Paulo, SP - Brazil

^[4] Superintendencia Controle Endemias Estado Sao Paul, Reg Serv 9, Sao Paulo - Brazil

^[5] Superintendencia Controle Endemias Estado Sao Paul, Lab Vectors Sao Jose do Rio Preto, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PARASITES & VECTORS; v. 11, SEP 10 2018.
• Citações Web of Science: 4

Resumo

Background: In Brazil, visceral leishmaniasis (VL) is a serious public health problem because of its magnitude, geographical expansion and potential harms caused by illnesses, including death. However, VL is largely ignored in discussions of tropical disease priorities. Thus, this study aimed to identify factors associated with the expansion of VL and the dispersion of its vector, Lutzomyia longipalpis, in the municipalities of the State of Sao Paulo, Brazil. Methods: Information about the date of vector detection and the confirmation of autochthonous VL occurrence in humans and canines in Sao Paulo were obtained between 1997 and 2014. Survival curves were calculated by the Kaplan-Meier and the Cox multiple regression models was used. Results: The presence of the Marechal Rondon highway showed the highest positive association with vector dispersion and canine and human VL expansion. The monthly maximum and minimum temperature averages recorded in the municipalities during the study period were also positively associated with these events. The presence of transverse highways was positively associated with the presence of the vector; the border with the State of Mato Grosso do Sul, the presence of a prison, microregion headquarters, and the presence of the Tiete River were positively associated with the occurrence of canine cases, while only the presence of prison was positively associated with the occurrence of human cases. The construction of the Bolivia-Brazil gas pipeline was not associated with any events. Conclusions: Survival analysis enabled the identification of factors associated with vector dispersion and VL expansion, thus the results of this study may be useful to the improvement of VL surveillance and control activities in the State of Sao Paulo and throughout Brazil. (AU)

• Processo FAPESP: 14/17764-6 - Estudo da expansão da leishmaniose visceral zoonótica no estado de São Paulo e avaliação das ações de controle nos municípios de Araçatuba e Birigui
• Beneficiário: Francisco Chiaravalloti Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular