Photobiomodulation induces antinociception, recovers structural aspects and regulates mitochondrial homeostasis in peripheral nerve of diabetic mice

Autor(es)

da Silva Oliveira, Victoria R. ^[1] ; Cury, Diego P. ^[2] ; Yamashita, Laura B. ^[1] ; Esteca, Marcos V. ^[3] ; Watanabe, Ii-Sei ^[2] ; Bergmann, Yoko Fee ^[1] ; Toniolo, Elaine F. ^{[1, 4]} ; Dale, Camila S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anat, Lab Neuromodulat Expt Pain, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Anat, Lab Ultrastruct Cells & Tissues, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Fac Sci Appl, Lab Cellular & Tissue Biol, Limeira - Brazil

^[4] Univ City Sao Paulo, Med Sch, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biophotonics; v. 11, n. 9 SEP 2018.
• Citações Web of Science: 1

Resumo

Diabetic peripheral neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement in peripheral nerves disabilities. In this work, the effects of PBM (660 nm, 30 mW, 1.6 J/cm(2), 0.28 cm(2), 15 s in a continuous frequency) on treating DPN-induced pain and nerve damage were evaluated in an experimental model of diabetic-neuropathy induced by streptozotocin in mice. PBM-induced antinociception in neuropathic-pain mice was dependent on central opioids release. After 21 consecutive applications, PBM increased nerve growth factor levels and induced structural recovery increasing mitochondrial content and regulating Parkin in the sciatic nerve of DPN-mice. Taking together, these data provide new insights into the mechanisms involved in the effects of PBM-therapy emphasizing its therapeutic potential in the treatment of DPN. (AU)

• Processo FAPESP: 16/10372-0 - Estudo dos mecanismos moleculares envolvidos na analgesia induzida por tratamento com laser de baixa intensidade na neuropatia periférica diabética experimental
• Beneficiário: Victória Regina da Silva Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/17136-8 - Estudo dos mecanismos moleculares envolvidos na analgesia induzida por tratamento com laser de baixa potência na neuropatia periférica experimental
• Beneficiário: Camila Squarzoni Dale
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/03270-1 - Efeito do laser de baixa potência na neuropatia periférica induzida por Diabetes Mellitus em camundongos
• Beneficiário: Laura Basilio Yamashita
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica