| Texto completo | |
| Autor(es): |
Soares, Ciro D.
[1]
;
Morais, Thayna M. L.
[1]
;
Carlos, Roman
[2]
;
Jorge, Jacks
[1]
;
de Almeida, Oslei Paes
[1]
;
de Carvalho, Maria G. F.
[3]
;
Altemani, Albina M. M.
[4]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Area Pathol, Piracicaba, SP - Brazil
[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala
[3] Private Pathol Serv, Natal, RN - Brazil
[4] Univ Estadual Campinas, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Histopathology; v. 73, n. 4, p. 585-592, OCT 2018. |
| Citações Web of Science: | 2 |
| Resumo | |
Aims: Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri-ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. Methods and results: We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31-90) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins (AE1AE3 and CK-5), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor XIIIa, S-100, vimentin and perforin. MLH1 and MSH2 were expressed in the nuclei of most tumour cells, and one case showed loss of MSH2 expression. Proliferative index (assessed by Ki-67 expression) and microvessel density (CD34-positive vessels) were higher in metastasis-associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity. Conclusions: The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool. (AU) | |
| Processo FAPESP: | 17/16102-8 - Papel biológico de RUNX1, Akt, COX-2 e metaloproteinases no mecanismo de metástase em melanomas |
| Beneficiário: | Jacks Jorge Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/25905-1 - Expressão de Akt, COX-2, RUNX1 e metaloproteinases em melanomas metastáticos e Prospecção biotecnológica de moléculas com atividade antitumoral |
| Beneficiário: | Ciro Dantas Soares |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |