Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Author(s)

Soares, Ciro D. ^[1] ; Morais, Thayna M. L. ^[1] ; Carlos, Roman ^[2] ; Jorge, Jacks ^[1] ; de Almeida, Oslei Paes ^[1] ; de Carvalho, Maria G. F. ^[3] ; Altemani, Albina M. M. ^[4]

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Area Pathol, Piracicaba, SP - Brazil

^[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala

^[3] Private Pathol Serv, Natal, RN - Brazil

^[4] Univ Estadual Campinas, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil

• Document type: Journal article
• Source: Histopathology; v. 73, n. 4, p. 585-592, OCT 2018.
• Web of Science Citations: 2

Abstract

Aims: Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri-ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. Methods and results: We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31-90) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins (AE1AE3 and CK-5), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor XIIIa, S-100, vimentin and perforin. MLH1 and MSH2 were expressed in the nuclei of most tumour cells, and one case showed loss of MSH2 expression. Proliferative index (assessed by Ki-67 expression) and microvessel density (CD34-positive vessels) were higher in metastasis-associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity. Conclusions: The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool. (AU)

• FAPESP's process: 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas
• Grantee: Jacks Jorge Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
• Grantee: Ciro Dantas Soares
• Support Opportunities: Scholarships in Brazil - Doctorate