Topical anti-inflammatory activity of palmitoleic acid improves wound healing

Autor(es)

Weimann, Elaine ^[1] ; Barros Silva, Maysa Braga ^[1] ; Murata, Gilson Masahiro ^[1] ; Bortolon, Jose Ricardo ^[1] ; Dermargos, Alexandre ^{[1, 2]} ; Curi, Rui ^[1] ; Hatanaka, Elaine ^[1]

Afiliação do(s) autor(es)

^[1] Univ Cruzeiro Sul, Inst Ciencias Atividade Fis & Esportes, Sao Paulo, SP - Brazil

^[2] Univ Paulista, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 13, n. 10 OCT 11 2018.
• Citações Web of Science: 1

Resumo

This study investigated the effects of palmitoleic acid on different phases of the healing process. Macroscopic analyses were performed on wounds in rats with or without palmitoleic acid treatment, and the results showed that palmitoleic acid directly hastened wound closure. The topical treatment of wounds with palmitoleic acid resulted in smaller wounds than those observed in the control group. The anti-inflammatory activity of palmitoleic acid may be responsible for healing, especially in the stages of granulation tissue formation and remodelling. Palmitoleic acid modified TNF-alpha, IL-1 beta, IL-6, CINC-2 alpha/beta, MIP-3 alpha and VEGF-alpha profiles at the wound site 24, 48, 120, 216 and 288 hours post-wounding. Assays assessing neutrophil migration and exudate formation in sterile inflammatory air pouches revealed that palmitoleic acid had potent anti-inflammatory activity, inhibiting the LPS-induced release of TNF-alpha (73.14%, p <= 0.05), IL-1 beta (66.19%, p <= 0.001), IL-6 (75.19%, p <= 0.001), MIP-3 alpha (70.38%, p <= 0.05), and 1-selectin (16%, p <= 0.05). Palmitoleic acid also inhibited LPS-stimulated neutrophil migration. We concluded that palmitoleic acid accelerates wound healing via an anti-inflammatory effect. (AU)

• Processo FAPESP: 11/15360-7 - Estudo do Ácido Palmitoleico nos Mecanismos Envolvidos no Processo de Cicatrização
• Beneficiário: Eleine Weimann
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/03947-1 - De ácidos oléico, linoléico, EPA e DHA sobre a função de queratinócitos: possível aplicação no tratamento tópico de feridas
• Beneficiário: Elaine Hatanaka Dermargos
• Modalidade de apoio: Auxílio à Pesquisa - Regular