Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Jaboticaba berry peel intake increases short chain fatty acids production and prevent hepatic steatosis in mice fed high-fat diet

Texto completo
Autor(es):
Batista, Angela Giovana [1, 2] ; da Silva-Maia, Juliana Kelly [1] ; Mendonca, Monique Culturato P. [3] ; Soares, Edilene Siqueira [3] ; Lima, Glaucia Carielo [1] ; Bogusz Junior, Stanislau [4] ; da Cruz-Hofling, Maria Alice [3] ; Marostica Junior, Mario Roberto [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Campinas Unicamp, Dept Food & Nutr, Fac Food Engn, Campinas, SP - Brazil
[2] Fed Univ Santa Maria UFSM, Dept Food & Nutr, Palmeira Das Missoes, RS - Brazil
[3] Univ Campinas Unicamp, Dept Biochem & Tissue Biol, Inst Biol, Campinas, SP - Brazil
[4] Univ Sao Paulo, Sao Carlos Inst Chem IQSC, Sao Carlos, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Functional Foods; v. 48, p. 266-274, SEP 2018.
Citações Web of Science: 5
Resumo

In this study, a preventive model was proposed to check whether the intake of Myrciaria jaboticaba berry peel (MJP) could avoid harmful effects caused by a high-fat diet. The intake of the high-fat diet supplemented with MJP (HM mice) down-regulated pro-inflammatory cytokines in adipose tissue and prevented adipose tissue growth and accumulation. In addition, the intake of the high-fat diet supplemented with MJP prevented weight gain, increased the excretion of triglycerides, reduced hepatic steatosis area and stimulated the production of short chain fatty acids (SCFA) by the large intestinal microbiota. Furthermore, hepatic mRNA PPAR-alpha level was lowered in non-fasted animals of the HM mice, indicating lower oxidation of both fatty acids and lipotoxic metabolites by the liver. In conclusion, MJP intake induces higher production of the gut SCFA, compounds known to counteract obesity markers, as shown by the lowering of adipose tissue inflammation, weight gain, dyslipidemia and hepatic steatosis. (AU)

Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
Beneficiário:Glaucia Maria Pastore
Modalidade de apoio: Auxílio à Pesquisa - Temático