| Full text | |
| Author(s): |
Batista, Angela Giovana
[1, 2]
;
da Silva-Maia, Juliana Kelly
[1]
;
Mendonca, Monique Culturato P.
[3]
;
Soares, Edilene Siqueira
[3]
;
Lima, Glaucia Carielo
[1]
;
Bogusz Junior, Stanislau
[4]
;
da Cruz-Hofling, Maria Alice
[3]
;
Marostica Junior, Mario Roberto
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Campinas Unicamp, Dept Food & Nutr, Fac Food Engn, Campinas, SP - Brazil
[2] Fed Univ Santa Maria UFSM, Dept Food & Nutr, Palmeira Das Missoes, RS - Brazil
[3] Univ Campinas Unicamp, Dept Biochem & Tissue Biol, Inst Biol, Campinas, SP - Brazil
[4] Univ Sao Paulo, Sao Carlos Inst Chem IQSC, Sao Carlos, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Functional Foods; v. 48, p. 266-274, SEP 2018. |
| Web of Science Citations: | 5 |
| Abstract | |
In this study, a preventive model was proposed to check whether the intake of Myrciaria jaboticaba berry peel (MJP) could avoid harmful effects caused by a high-fat diet. The intake of the high-fat diet supplemented with MJP (HM mice) down-regulated pro-inflammatory cytokines in adipose tissue and prevented adipose tissue growth and accumulation. In addition, the intake of the high-fat diet supplemented with MJP prevented weight gain, increased the excretion of triglycerides, reduced hepatic steatosis area and stimulated the production of short chain fatty acids (SCFA) by the large intestinal microbiota. Furthermore, hepatic mRNA PPAR-alpha level was lowered in non-fasted animals of the HM mice, indicating lower oxidation of both fatty acids and lipotoxic metabolites by the liver. In conclusion, MJP intake induces higher production of the gut SCFA, compounds known to counteract obesity markers, as shown by the lowering of adipose tissue inflammation, weight gain, dyslipidemia and hepatic steatosis. (AU) | |
| FAPESP's process: | 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops |
| Grantee: | Glaucia Maria Pastore |
| Support Opportunities: | Research Projects - Thematic Grants |