Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration

Autor(es)

Roggerio, Alessandra ^[1] ; Cassaro Strunz, Celia M. ^[1] ; Pacanaro, Ana Paula ^[1] ; Leal, Dalila Pinheiro ^[1] ; Takada, Julio Y. ^[1] ; Avakian, Solange D. ^[1] ; Mansur, Antonio de Padua ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao, Av Dr Eneas Carvalho Aguiar 44, BR-05403900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 10, n. 7 JUL 2018.
• Citações Web of Science: 5

Resumo

Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product (esRAGE) are associated with vascular protection. The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. The study included 48 healthy subjects randomized to 30 days of RSV (500 mg/day) or CR (1000 cal/day). Waist circumference (p = 0.011), TC (p = 0.007), HDL (p = 0.031), non-HDL (p = 0.025), ApoA1 (p = 0.011), and ApoB (p = 0.037) decreased in the CR group. However, TC (p = 0.030), non-HDL (p = 0.010), ApoB (p = 0.034), and HOMA-IR (p = 0.038) increased in the RSV group. RSV and CR increased serum levels of Sirt-1, respectively, from 1.06 +/- 0.71 ng/mL to 5.75 +/- 2.98 ng/mL (p < 0.0001) and from 1.65 +/- 1.81 ng/mL to 5.80 +/- 2.23 ng/mL (p < 0.0001). esRAGE serum levels were similar in RSV (p = NS) and CR (p = NS) groups. Significant positive correlation was observed between gene expression changes of Sirt-1 and esRAGE in RSV (r = 0.86; p < 0.0001) and in CR (r = 0.71; p < 0.0001) groups, but not for the changes in serum concentrations. CR promoted increases in the gene expression of esRAGE (post/pre). Future long-term studies are needed to evaluate the impact of these outcomes on vascular health. (AU)

• Processo FAPESP: 12/01051-5 - Influência da restrição calórica e do resveratrol no sistema da sirtuína em mulheres e homens com idade entre 55 e 65 anos
• Beneficiário: Antonio de Padua Mansur
• Modalidade de apoio: Auxílio à Pesquisa - Regular