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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration

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Roggerio, Alessandra [1] ; Cassaro Strunz, Celia M. [1] ; Pacanaro, Ana Paula [1] ; Leal, Dalila Pinheiro [1] ; Takada, Julio Y. [1] ; Avakian, Solange D. [1] ; Mansur, Antonio de Padua [1]
Total Authors: 7
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao, Av Dr Eneas Carvalho Aguiar 44, BR-05403900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NUTRIENTS; v. 10, n. 7 JUL 2018.
Web of Science Citations: 5

Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product (esRAGE) are associated with vascular protection. The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. The study included 48 healthy subjects randomized to 30 days of RSV (500 mg/day) or CR (1000 cal/day). Waist circumference (p = 0.011), TC (p = 0.007), HDL (p = 0.031), non-HDL (p = 0.025), ApoA1 (p = 0.011), and ApoB (p = 0.037) decreased in the CR group. However, TC (p = 0.030), non-HDL (p = 0.010), ApoB (p = 0.034), and HOMA-IR (p = 0.038) increased in the RSV group. RSV and CR increased serum levels of Sirt-1, respectively, from 1.06 +/- 0.71 ng/mL to 5.75 +/- 2.98 ng/mL (p < 0.0001) and from 1.65 +/- 1.81 ng/mL to 5.80 +/- 2.23 ng/mL (p < 0.0001). esRAGE serum levels were similar in RSV (p = NS) and CR (p = NS) groups. Significant positive correlation was observed between gene expression changes of Sirt-1 and esRAGE in RSV (r = 0.86; p < 0.0001) and in CR (r = 0.71; p < 0.0001) groups, but not for the changes in serum concentrations. CR promoted increases in the gene expression of esRAGE (post/pre). Future long-term studies are needed to evaluate the impact of these outcomes on vascular health. (AU)

FAPESP's process: 12/01051-5 - Influence of caloric restriction and resveratrol in the sirtuin system in women and men aged 55 to 65 years
Grantee:Antonio de Padua Mansur
Support type: Regular Research Grants