Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment?

Autor(es)

dos Anjos, Laura Gonzalez ^[1] ; de Almeida, Bruna Cristine ^[1] ; de Almeida, Thais Gomes ^{[1, 2]} ; Lavorato Rocha, Andre Mourao ^[3] ; Maffazioli, Giovana De Nardo ^[1] ; Soares, Fernando Augusto ^{[3, 4, 5]} ; da Cunha, Isabela Werneck ^{[3, 4, 5]} ; Baracat, Edmund Chada ^[1] ; Carvalho, Katia Candido ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin, Fac Med, Disciplina Ginecol, HCFMUSP, SP, Dept Obstet & Ginecol, Lab Ginecol Estrutural & Mo, BR Ave Dr Arnaldo 455, Sala 4121, BR-05403010 Sao Paulo - Brazil

^[2] Inst Brasileiro Controle Canc, SP, BR Ave Alcantara Machado, 2576 Mooca, BR-05403010 Sao Paulo - Brazil

^[3] Hosp AC Camargo Canc Ctr, SP, BR R Tamandare, 753 Liberdade, BR-05403010 Sao Paulo - Brazil

^[4] Rede DOR Sao Luiz, Dept Pathol, Rua Perobas, 344 Jabaquara, BR-04321120 Sao Paulo - Brazil

^[5] Natl Inst Sci & Technol Oncogen & Therapeut Innov, SP, BR R Tamandare, 753 Liberdade, BR-05403010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CANCERS; v. 10, n. 9 SEP 2018.
• Citações Web of Science: 8

Resumo

Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing about 1% of all gynecologic neoplasms. This study aimed to assess the expression profile of 84 cancer-related miRNAs and to evaluate their correlation with clinical pathological features. Eighty-two formalin-fixed paraffin-embedded (FFPE) samples were selected. In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p. In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124. In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS. Only miR-138-5p upregulation was associated with higher survival rates. miR-335-5p, miR-301a-3p, and miR-210-3p were more highly expressed in patients with tumor metastasis and relapse. miR-138-5p, miR-146b-5p, and miR-218-5p expression were associated with higher disease-free survival (DFS) in treated patients. These miRNAs represent potential prediction markers for prognosis and treatment response in these tumors. (AU)

• Processo FAPESP: 12/23652-0 - Análise molecular de mecanismos envolvidos na regulação da expressão dos fatores de crescimento EGF, VEGF, HER2 e do fator de transcrição foxo3 em sarcomas uterinos
• Beneficiário: Kátia Cândido Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular