| Full text | |
| Author(s): |
dos Anjos, Laura Gonzalez
[1]
;
de Almeida, Bruna Cristine
[1]
;
de Almeida, Thais Gomes
[1, 2]
;
Lavorato Rocha, Andre Mourao
[3]
;
Maffazioli, Giovana De Nardo
[1]
;
Soares, Fernando Augusto
[3, 4, 5]
;
da Cunha, Isabela Werneck
[3, 4, 5]
;
Baracat, Edmund Chada
[1]
;
Carvalho, Katia Candido
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Hosp Clin, Fac Med, Disciplina Ginecol, HCFMUSP, SP, Dept Obstet & Ginecol, Lab Ginecol Estrutural & Mo, BR Ave Dr Arnaldo 455, Sala 4121, BR-05403010 Sao Paulo - Brazil
[2] Inst Brasileiro Controle Canc, SP, BR Ave Alcantara Machado, 2576 Mooca, BR-05403010 Sao Paulo - Brazil
[3] Hosp AC Camargo Canc Ctr, SP, BR R Tamandare, 753 Liberdade, BR-05403010 Sao Paulo - Brazil
[4] Rede DOR Sao Luiz, Dept Pathol, Rua Perobas, 344 Jabaquara, BR-04321120 Sao Paulo - Brazil
[5] Natl Inst Sci & Technol Oncogen & Therapeut Innov, SP, BR R Tamandare, 753 Liberdade, BR-05403010 Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | CANCERS; v. 10, n. 9 SEP 2018. |
| Web of Science Citations: | 8 |
| Abstract | |
Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing about 1% of all gynecologic neoplasms. This study aimed to assess the expression profile of 84 cancer-related miRNAs and to evaluate their correlation with clinical pathological features. Eighty-two formalin-fixed paraffin-embedded (FFPE) samples were selected. In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p. In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124. In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS. Only miR-138-5p upregulation was associated with higher survival rates. miR-335-5p, miR-301a-3p, and miR-210-3p were more highly expressed in patients with tumor metastasis and relapse. miR-138-5p, miR-146b-5p, and miR-218-5p expression were associated with higher disease-free survival (DFS) in treated patients. These miRNAs represent potential prediction markers for prognosis and treatment response in these tumors. (AU) | |
| FAPESP's process: | 12/23652-0 - Molecular analysis of the mechanisms involved in the regulation of EGF, VEGF, HER2 and of the transcriptional factor Foxo3 expression in uterine sarcoma |
| Grantee: | Kátia Cândido Carvalho |
| Support Opportunities: | Regular Research Grants |