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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

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Autor(es):
Pruper de Freitas, Maria Camila [1] ; Estevez Fernandez, Diana Gabriela [2] ; Cohen, Danielle [2] ; Figueiredo-Neto, Antonio Martins [3] ; Maranhao, Raul Cavalcante [4, 5] ; Teixeira Damasceno, Nagila Raquel [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Programa Interunidades Nutr Humana Aplicada, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Fis, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Metab Lipides, Inst Coracao, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 73, 2018.
Citações Web of Science: 1
Resumo

OBJECTIVES: To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents. METHODS: This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68). RESULTS: As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein {[}LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents. CONCLUSIONS: Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents. (AU)

Processo FAPESP: 11/12523-2 - Propriedades físico-químicas da LDL e da HDL, marcadores cardiometabólicos e oxidativos podem ser modulados pelo consumo de ômega-3, ômega-6 e ômega-9 em indivíduos adultos?
Beneficiário:Nágila Raquel Teixeira Damasceno
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/13616-4 - Propriedades ópticas e estruturais de elastômeros e fluidos complexos de interesse biológico
Beneficiário:Antonio Martins Figueiredo Neto
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/06565-5 - Desenvolvimento de um Escore de Funcionalidade da Lipoproteína de Alta Densidade (HDL) e sua Associação com Algoritmos de Predição de Risco Cardiovascular e Desfechos Clínicos em Indivíduos Brasileiros
Beneficiário:Maria Camila Pruper de Freitas
Linha de fomento: Bolsas no Brasil - Doutorado