| Texto completo | |
| Autor(es): |
Negrin, Ana Carolina
[1]
;
de Jesus, Mariana Marcielo
[1]
;
Christante, Caroline Maria
[1]
;
Humberto da Silva, Danilo Grunig
[2]
;
Taboga, Sebastiao Roberto
[1, 3]
;
Pinto-Fochi, Maria Etelvina
[3, 4]
;
Goes, Rejane Maira
[1, 3]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Campinas UNICAMP, Inst Biol, Dept Funct & Struct Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Rua Cristovao Colombo, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[4] UNILAGO, Unido Fac Grandes Lagos, Fac Med, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | REPRODUCTIVE TOXICOLOGY; v. 81, p. 168-179, OCT 2018. |
| Citações Web of Science: | 3 |
| Resumo | |
This study evaluated the consequences of gestational exposure to di-n-butyl phthalate (DBP) for testicular steroidogenesis and sperm parameters of the adult gerbil and the interference of corn oil (co), a vehicle widely used for administration of liposoluble agents, on DBP effects. Pregnant gerbils received no treatment or were treated from gestational day 8 to 23 via gavage with 0.1 mL/day of co only or containing DBP (100 mg/kg/day). Maternal co intake enhanced serum estradiol levels and testicular content of ERa, and reduced sperm reserve of adult offspring. Gestational DBP exposure caused dyslipidemia, increased serum and intratesticular estradiol levels and reduced sperm reserve and motility. Thus, maternal co supplementation alters circulating estradiol and impairs sperm quantity and quality of offspring. Gestational DBP exposure alters lipid metabolism and testicular steroidogenesis and worsens the negative effects of co on the sperm reserve and motility of gerbil. Therefore, co interferes with the reproductive response to DBP. (AU) | |
| Processo FAPESP: | 13/16368-7 - Influência da melatonina exógena na resposta tecidual da próstata de ratos ao diabetes experimental e interferência na ação androgênica e insulínica |
| Beneficiário: | Rejane Maira Góes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/04146-2 - Interferências da exposição in utero ao di-n-butil ftalato e do consumo excessivo de lipídeos saturados para os parâmetros reprodutivos do gerbilo |
| Beneficiário: | Ana Carolina Negrin |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |