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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve

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Author(s):
Negrin, Ana Carolina [1] ; de Jesus, Mariana Marcielo [1] ; Christante, Caroline Maria [1] ; Humberto da Silva, Danilo Grunig [2] ; Taboga, Sebastiao Roberto [1, 3] ; Pinto-Fochi, Maria Etelvina [3, 4] ; Goes, Rejane Maira [1, 3]
Total Authors: 7
Affiliation:
[1] Univ Campinas UNICAMP, Inst Biol, Dept Funct & Struct Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Rua Cristovao Colombo, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[4] UNILAGO, Unido Fac Grandes Lagos, Fac Med, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 81, p. 168-179, OCT 2018.
Web of Science Citations: 3
Abstract

This study evaluated the consequences of gestational exposure to di-n-butyl phthalate (DBP) for testicular steroidogenesis and sperm parameters of the adult gerbil and the interference of corn oil (co), a vehicle widely used for administration of liposoluble agents, on DBP effects. Pregnant gerbils received no treatment or were treated from gestational day 8 to 23 via gavage with 0.1 mL/day of co only or containing DBP (100 mg/kg/day). Maternal co intake enhanced serum estradiol levels and testicular content of ERa, and reduced sperm reserve of adult offspring. Gestational DBP exposure caused dyslipidemia, increased serum and intratesticular estradiol levels and reduced sperm reserve and motility. Thus, maternal co supplementation alters circulating estradiol and impairs sperm quantity and quality of offspring. Gestational DBP exposure alters lipid metabolism and testicular steroidogenesis and worsens the negative effects of co on the sperm reserve and motility of gerbil. Therefore, co interferes with the reproductive response to DBP. (AU)

FAPESP's process: 14/04146-2 - Interference of in utero exposure to di-n-butyl phthalate and excessive consumption of saturated fat to reproductive parameters of gerbil
Grantee:Ana Carolina Negrin
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/16368-7 - Influence of exogen melatonin on rat prostate tissue response to experimental diabetes and interference on androgen and insulin actions
Grantee:Rejane Maira Góes
Support type: Regular Research Grants