Conjugation of antifungal benzoic acid derivatives as a path for detoxification in Penicillium brasilianum, an endophyte from Melia azedarach

Autor(es)

Fill, Taicia Pacheco ^[1] ; Pallini, Heloisa Fassina ^[2] ; Din, Zia Ud ^[2] ; Jurberg, Igor Dias ^[1] ; da Silva, Jose Vinicius ^[2] ; Rodrigues-Filho, Edson ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, CP 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, CP 676, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOORGANIC CHEMISTRY; v. 81, p. 367-372, DEC 2018.
• Citações Web of Science: 0

Resumo

In this study, the consumption of 4-bromobenzoic acid and 4-chlorobenzoic acid by the fungus Penicillium brasilianum, an endophyte from Melia azedarach is evaluated. This fungus metabolizes these halobenzoic acids to produce three new brominated compounds, which have been isolated and characterized, and three new chlorinated derivatives identified by HRMS. Among these products, (4-bromobenzoyl)proline has been also chemically synthesized and employed in biological assays, thus providing insights for the elucidation of the defense mechanism of P. brasilianum towards these halobenzoic acids. (AU)

• Processo FAPESP: 10/11384-6 - Biotransformação de produtos naturais e sintéticos utilizando micro-organismos endofíticos, uma abordagem quimio-ecológica para a produção de substâncias bioativas
• Beneficiário: Edson Rodrigues Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/10384-6 - Estudos biossintéticos utilizando abordagens bottom-up de policetídeos produzidos por fungos do gênero Penicillium
• Beneficiário: Taicia Pacheco Fill
• Modalidade de apoio: Auxílio à Pesquisa - Regular