| Texto completo | |
| Autor(es): |
Rueda Furlan, Joao Pedro
[1]
;
Sanchez, Danilo Garcia
[1]
;
Lage Gallo, Inara Fernanda
[1]
;
Stehling, Eliana Guedes
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MICROBIAL DRUG RESISTANCE; v. 25, n. 4 NOV 2018. |
| Citações Web of Science: | 3 |
| Resumo | |
Stenotrophomonas maltophilia is an opportunist pathogen that has intrinsic resistance to the majority of antibiotics and has a high ability to adapt in different environments; however, there are few reports of acquired resistance genes in S. maltophilia. The aim of this study was to investigate the antimicrobial resistance profile, the presence of mutations in the quinolone-resistance determining region, the presence of acquired resistance genes, and the different plasmid families in S. maltophilia isolated from Brazilian soils. A total of 16 isolates were obtained from a variety of agricultural soils with different cultures of Brazil and they were nonsusceptible to most of the antibiotics tested. No mutations were detected in the gyrA gene and only one (Ser-80-Ile) was detected in the parC gene. A diversity of acquired resistance genes was found, including the qnrA, qnrB, qnrS, oqxA, oqxB, bla(SHV), bla(CTX-M-Gp1), bla(PER), bla(OXA-1-like), bla(OXA-48-like), and sul1. All isolates presented ColE-like plasmids and only one presented IncL/M. These results show, for the first time, the presence of qnrA and oqxAB genes and the presence of qnrB and qnrS genes for the second time in the world in S. maltophilia. (AU) | |
| Processo FAPESP: | 15/18990-2 - Investigação dos mecanismos de resistência às quinolonas em isolados bacterianos ambientais |
| Beneficiário: | Eliana Guedes Stehling |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |