Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp Marine Sponge Collected at the Amazon River Mouth

Autor(es):Mostrar menos -

de Souza, Renata T. M. P. ^[1] ; Freire, Vitor F. ^[1] ; Gubiani, Juliana R. ^[1] ; Ferreira, Raquel O. ^[2] ; Trivella, Daniela B. B. ^[2] ; Moraes, Fernando C. ^[3] ; Paradas, Wladimir C. ^[3] ; Salgado, Leonardo T. ^[3] ; Pereira, Renato C. ^{[3, 4]} ; Amado Filho, Gilberto M. ^[3] ; Ferreira, Antonio G. ^[5] ; Williams, David E. ^{[6, 7]} ; Andersen, Raymond J. ^{[6, 7]} ; Molinski, Tadeusz F. ^{[8, 9]} ; Berlinck, Roberto G. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil

^[2] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil

^[3] Inst Pesquisas Jardim Bot Rio de Janeiro, R Pacheco Leao 915, BR-22460030 Rio De Janeiro, RJ - Brazil

^[4] Univ Fed Fluminense, Inst Biol, Dept Biol Marinha, POB 100-644, BR-24001970 Niteroi, RJ - Brazil

^[5] Univ Fed Sao Carlos, Dept Quim, Rod Washington Luiz, Km 235 SP 310, BR-13565905 Sao Carlos, SP - Brazil

^[6] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada

^[7] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada

^[8] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA

^[9] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 81, n. 10, p. 2296-2300, OCT 2018.
• Citações Web of Science: 1

Resumo

The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series. (AU)

• Processo FAPESP: 13/50228-8 - Componentes da biodiversidade, e seus caracteres metabólicos, de ilhas do Brasil: uma abordagem integrada
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático