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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp Marine Sponge Collected at the Amazon River Mouth

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Author(s):
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de Souza, Renata T. M. P. [1] ; Freire, Vitor F. [1] ; Gubiani, Juliana R. [1] ; Ferreira, Raquel O. [2] ; Trivella, Daniela B. B. [2] ; Moraes, Fernando C. [3] ; Paradas, Wladimir C. [3] ; Salgado, Leonardo T. [3] ; Pereira, Renato C. [3, 4] ; Amado Filho, Gilberto M. [3] ; Ferreira, Antonio G. [5] ; Williams, David E. [6, 7] ; Andersen, Raymond J. [6, 7] ; Molinski, Tadeusz F. [8, 9] ; Berlinck, Roberto G. S. [1]
Total Authors: 15
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil
[3] Inst Pesquisas Jardim Bot Rio de Janeiro, R Pacheco Leao 915, BR-22460030 Rio De Janeiro, RJ - Brazil
[4] Univ Fed Fluminense, Inst Biol, Dept Biol Marinha, POB 100-644, BR-24001970 Niteroi, RJ - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, Rod Washington Luiz, Km 235 SP 310, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada
[7] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada
[8] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA
[9] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA
Total Affiliations: 9
Document type: Journal article
Source: Journal of Natural Products; v. 81, n. 10, p. 2296-2300, OCT 2018.
Web of Science Citations: 0
Abstract

The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants