Bromopyrrole alkaloids from the cultured microbiome of the marine sponge Tedania b...
| Full text | |
| Author(s): Show less - |
de Souza, Renata T. M. P.
[1]
;
Freire, Vitor F.
[1]
;
Gubiani, Juliana R.
[1]
;
Ferreira, Raquel O.
[2]
;
Trivella, Daniela B. B.
[2]
;
Moraes, Fernando C.
[3]
;
Paradas, Wladimir C.
[3]
;
Salgado, Leonardo T.
[3]
;
Pereira, Renato C.
[3, 4]
;
Amado Filho, Gilberto M.
[3]
;
Ferreira, Antonio G.
[5]
;
Williams, David E.
[6, 7]
;
Andersen, Raymond J.
[6, 7]
;
Molinski, Tadeusz F.
[8, 9]
;
Berlinck, Roberto G. S.
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil
[3] Inst Pesquisas Jardim Bot Rio de Janeiro, R Pacheco Leao 915, BR-22460030 Rio De Janeiro, RJ - Brazil
[4] Univ Fed Fluminense, Inst Biol, Dept Biol Marinha, POB 100-644, BR-24001970 Niteroi, RJ - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, Rod Washington Luiz, Km 235 SP 310, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada
[7] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada
[8] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA
[9] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr MC 0358, La Jolla, CA 92093 - USA
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 81, n. 10, p. 2296-2300, OCT 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series. (AU) | |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support type: | BIOTA-FAPESP Program - Thematic Grants |