| Grant number: | 11/18564-2 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | January 01, 2012 |
| Effective date (End): | June 30, 2015 |
| Field of knowledge: | Health Sciences - Pharmacy - Toxicological Analysis |
| Principal Investigator: | Pio Colepicolo Neto |
| Grantee: | Daniel Xavier Andreguetti |
| Host Institution: | Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 10/50193-1 - Marine algae as source of metabolites of economical impact, AP.BTA.TEM |
Abstract Nowadays the pharmaceutical industry has devoted so many researches to search for new drugs to treat diseases caused by the action of microorganisms like bacteria and fungi, different types of cancer and diseases related to oxidative mechanisms as well. Many drugs currently used are derived from chemical molecules isolated from organisms found in nature or based on these. Some drugs are also described as isolated from marine organisms such as corals, sponges and algae, organisms which produce a large amount of secondary metabolites. Based on this fact, the present study aims is to conduct the exploration of potential bioactive antioxidant, antibacterial, antifungal and anticancer compounds in extracts of marine algae of the genus Dictyota and Chondria collected in the São Paulo state coast. The extracts will be obtained through supercritical fluid extraction methods, in order to obtain the largest amount of chemical structures as possible, and then, will have their chromatographic profiles assessed by analytical HPLC-MS and GC-MS. Evaluation of antioxidant potential will be realized for two methods, the method of DPPH and evaluation of the radical scavenger activity of superoxide (O2 *-). The cytotoxic potential against microorganisms will be evaluated by determination of the minimum inhibitory concentration by microdilution and minimal lethal concentration methods in cultures of fungi and bacteria, both human pathogens. Evaluation of cytotoxic potential against cancer cells will be accomplished through exposure of extracts from the cell line MES-SA and its multidrug resistant MES-SA/Dx5 variable line. | |
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