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Prospecting of antioxidants, antibiotics and anticancer bioactive compounds in marine algae of the genus Chondria (Rhodophyta) and Dictyota (Phaeophyta) collected on the coast of São Paulo State

Grant number: 11/18564-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2012
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal researcher:Pio Colepicolo Neto
Grantee:Daniel Xavier Andreguetti
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:10/50193-1 - Marine algae as source of metabolites of economical impact, AP.BTA.TEM

Abstract

Nowadays the pharmaceutical industry has devoted so many researches to search for new drugs to treat diseases caused by the action of microorganisms like bacteria and fungi, different types of cancer and diseases related to oxidative mechanisms as well. Many drugs currently used are derived from chemical molecules isolated from organisms found in nature or based on these. Some drugs are also described as isolated from marine organisms such as corals, sponges and algae, organisms which produce a large amount of secondary metabolites. Based on this fact, the present study aims is to conduct the exploration of potential bioactive antioxidant, antibacterial, antifungal and anticancer compounds in extracts of marine algae of the genus Dictyota and Chondria collected in the São Paulo state coast. The extracts will be obtained through supercritical fluid extraction methods, in order to obtain the largest amount of chemical structures as possible, and then, will have their chromatographic profiles assessed by analytical HPLC-MS and GC-MS. Evaluation of antioxidant potential will be realized for two methods, the method of DPPH and evaluation of the radical scavenger activity of superoxide (O2 *-). The cytotoxic potential against microorganisms will be evaluated by determination of the minimum inhibitory concentration by microdilution and minimal lethal concentration methods in cultures of fungi and bacteria, both human pathogens. Evaluation of cytotoxic potential against cancer cells will be accomplished through exposure of extracts from the cell line MES-SA and its multidrug resistant MES-SA/Dx5 variable line.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
STEIN, ERIKA M.; MACHADO, LEVI P.; ROFFATO, HENRIQUE K.; MIYASATO, PATRICIA A.; NAKANO, ELIANA; COLEPICOLO, PIO; ANDREGUETTI, DANIEL X. Antischistosomal activity from Brazilian marine algae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 6, p. 663-667, NOV-DEC 2015. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.