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Marine algae as source of metabolites of economical impact

Grant number: 10/50193-1
Support type:BIOTA-FAPESP Program - Thematic Grants
Duration: August 01, 2010 - July 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Oceanography
Principal Investigator:Pio Colepicolo Neto
Grantee:Pio Colepicolo Neto
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):12/00933-4 - Biochemical biomarkers in macroalgae of the genus Gracilaria exposed to metals, BP.DR
12/12235-0 - Identification of metal stress response transcripts in Gracilaria domingensis, BP.DR
11/16072-5 - Use of genetic and biochemical engeneiring in Chlamydomonas reinhardtii aiming the increase of the lipid level for biofuel production, BP.MS
+ associated scholarships 11/18564-2 - Prospecting of antioxidants, antibiotics and anticancer bioactive compounds in marine algae of the genus Chondria (Rhodophyta) and Dictyota (Phaeophyta) collected on the Coast of São Paulo state, BP.DR
11/10155-6 - Bioprospecting for metabolites and molecular systematics of red algae Laurencia aldingensis and Laurencia SP. (Ceramiales, Rhodomelaceae), BP.DR
10/04856-9 - Enzymatic activity and analysis of gene expression of nitrate reductase in the macrophyte Gracilaria birdiae (Gracilariales, Rhodophyta) during light/dark cycle, BP.MS
10/14893-9 - Study of metabolic effects of anthracene on microalgae Chlamydomonas reinhardtii, BP.DR - associated scholarships

Abstract

In order to survive in a highly competitive environment, marine algae have to develop defense strategies that result in a tremendous diversity of compounds from different metabolic pathways. Recent trends in drug research from natural sources have shown that algae are promising organisms to furnish novel biochemically active compounds. The aim of this project is to study the compounds biosynthesized by algae with potential economic impact in food science, pharmaceutical industry and public health. Emphasis is given to antioxidants, bactericide, antifungal and UV absorber molecules. Macroalgae will be collected at Sao Paulo State marine coastal and assays will be performed at the lab. Extracts with potential activities will be purifies and the chemical structure will be elucidated. (AU)

Articles published in Revista Pesquisa FAPESP about the project
Marine versatility 

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PACHECO, BRUNA SILVEIRA; ZIEMANN DOS SANTOS, MARCO AURELIO; SCHULTZE, EDUARDA; MARTINS, ROSIANE MASTELARI; LUND, RAFAEL GUERRA; SEIXAS, FABIANA KOMMLING; COLEPICOLO, PIO; COLLARES, TIAGO; PAULA, FAVERO REISDORFER; PEREIRA DE PEREIRA, CLAUDIO MARTIN. Cytotoxic Activity of Fatty Acids From Antarctic Macroalgae on the Growth of Human Breast Cancer Cells. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 6, DEC 3 2018. Web of Science Citations: 0.
MARTINS, ALINE P.; ZAMBOTTI-VILLELA, LEONARDO; YOKOYA, NAIR S.; COLEPICOLO, PIO. Biotechnological potential of benthic marine algae collected along the Brazilian coast. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 33, p. 316-327, JUL 2018. Web of Science Citations: 0.
ALVES-LIMA, CICERO; CAVACANA, NATALE; TEIXEIRA CHAVES, GUSTAVO ANTONIO; DE LIMA, NATALIA OLIVEIRA; STEFANELLO, ELIEZER; COLEPICOLO, PIO; HOTTA, CARLOS TAKESHI. Reference genes for transcript quantification in Gracilaria tenuistipitata under drought stress. JOURNAL OF APPLIED PHYCOLOGY, v. 29, n. 2, p. 731-740, APR 2017. Web of Science Citations: 2.
ROMANO, RENATO LAHOS; LIRIA, CLEBER WANDERLEI; TERSA MACHINI, M.; COLEPICOLO, PIO; ZAMBOTTI-VILLELA, LEONARDO. Cadmium decreases the levels of glutathione and enhances the phytochelatin concentration in the marine dinoflagellate Lingulodinium polyedrum. JOURNAL OF APPLIED PHYCOLOGY, v. 29, n. 2, p. 811-820, APR 2017. Web of Science Citations: 6.
MARTINS, ALINE P.; YOKOYA, NAIR S.; COLEPICOLO, PIO. Biochemical Modulation by Carbon and Nitrogen Addition in Cultures of Dictyota menstrualis (Dictyotales, Phaeophyceae) to Generate Oil-based Bioproducts. MARINE BIOTECHNOLOGY, v. 18, n. 3, p. 314-326, JUN 2016. Web of Science Citations: 4.
SIMAS-RODRIGUES, CNTIA; VILLELA, HELENA D. M.; MARTINS, ALINE P.; MARQUES, LUIZA G.; COLEPICOLO, PIO; TONON, ANGELA P. Microalgae for economic applications: advantages and perspectives for bioethanol. Journal of Experimental Botany, v. 66, n. 14, SI, p. 4097-4108, JUL 2015. Web of Science Citations: 18.
CASSANO, VALERIA; OLIVEIRA, MARIANA C.; CANDELARIA GIL-RODRIGUEZ, MA; SENTIES, ABEL; DIAZ-LARREA, JHOANA; FUJII, MUTUE T. Morphological and molecular studies on the Brazilian native red seaweed Laurencia oliveirana (Rhodomelaceae, Ceramiales). REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 22, n. 4, p. 838-849, JUL-AUG 2012. Web of Science Citations: 1.
FUJII, MUTUE T.; CASSANO, VALERIA; STEIN, ERIKA M.; CARVALHO, LUCIANA R. Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 21, n. 2, p. 268-282, MAR-APR 2011. Web of Science Citations: 28.

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