Bark of Passiflora edulis Treatment Stimulates Antioxidant Capacity, and Reduces Dyslipidemia and Body Fat in db/db Mice

Autor(es):Mostrar menos -

Panelli, Marielle Fernanda ^[1] ; Pierine, Damiana Tortolero ^[1] ; Borges de Souza, Sergio Luiz ^[1] ; Togneri Ferron, Artur Junio ^[1] ; Garcia, Jessica Leite ^[1] ; dos Santos, Klinsmann Carolo ^[1] ; Filiol Belin, Matheus Antonio ^[2] ; Pereira Lima, Giuseppina Pace ^[2] ; Borguini, Milena Galhardo ^[2] ; Minatel, Igor Otavio ^{[1, 2]} ; Cicogna, Antonio Carlos ^[1] ; Francisqueti, Fabiane Valentini ^[1] ; Correa, Camila Renata ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Med, BR-18618687 Botucatu, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Biosci Inst, BR-18618689 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANTIOXIDANTS; v. 7, n. 9 SEP 2018.
• Citações Web of Science: 5

Resumo

Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p < 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice. (AU)

• Processo FAPESP: 15/09292-0 - Efeito da farinha da casca de maracujá (Passiflora edulis) sobre o estresse oxidativo, perfil metabólico e histológico na obesidade
• Beneficiário: Marielle Fernanda Panelli
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica