The Route of Administration Exacerbates Prefrontal Functional Impairments in Crack Cocaine Users

Autor(es)

Oliveira, Hercilio P. ^[1] ; Goncalves, Priscila D. ^[1] ; Ometto, Mariella ^[1] ; Santos, Bernardo ^[2] ; Malbergier, Andre ^[1] ; Amaral, Ricardo ^[1] ; Nicastri, Sergio ^[3] ; Andrade, Arthur G. ^[3] ; Cunha, Paulo J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Psiquiatria, Fac Med, Hosp Clin, 785 Rua Dr Ovidio Pires de Campos, BR-05403903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Enfermagem, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Psiquiatria, Fac Med, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PSYCHOLOGY OF ADDICTIVE BEHAVIORS; v. 32, n. 7, p. 812-820, NOV 2018.
• Citações Web of Science: 1

Resumo

Studies have evidenced more severe health consequences in individuals who smoked crack cocaine as compared to intranasal cocaine users. Differential neurocognitive deficits between the crack and intranasal cocaine-addicted patients, associated with prefrontal cortex functions, have never been tested using complex cognitive tasks in humans. In this study, we examined possible distinct neurocognitive deficits in 43 crack-addicted patients (CrD) compared with 36 intranasal cocaine-addicted patients (CD) and 32 controls. CrD and CD were evaluated after 2 weeks of supervised detoxification in two inpatient treatment programs. All the subjects were evaluated using an extensive battery of neurocognitive tasks, including the Trail Making Test, the Stroop Color-Word Test, the Digits Forward and Digits Backward tasks, the Controlled Oral Word Association Test, the Wechsler Adult Intelligence Scale, and the Frontal Assessment Battery. Differences in performance in the neurocognitive tests between the three groups were investigated controlling for age, IQ, psychiatric symptoms, and years of education. Both intranasal and crack users were impaired on a variety of cognitive measures relative to controls. Crack users performed worse than intranasal cocaine users in inhibitory control (p = .05) and general executive functioning (p = .01). Crack use seems to be more deleterious to neurocognitive functions associated with the prefrontal cortex. This may predispose crack-addicted patients to more severe negative clinical outcomes. (AU)

• Processo FAPESP: 11/19179-5 - Compatibilidade estímulo-resposta e valência emocional: uma investigação das bases neurológicas envolvidas no processamento da informação espacial e emocional
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/01272-6 - Pesquisa sobre o impacto da reabilitação neuropsicológica em dependentes de cocaína/crack
• Beneficiário: Priscila Dib Goncalves
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/15604-0 - Integridade de substância branca em corpo caloso e desempenho neuropsicológico em crianças e adolescentes vítimas de violência e maus tratos: estudo morfométrico cerebral e de imagem por tensores de difusão
• Beneficiário: Paulo Jannuzzi Cunha
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 00/12081-5 - Alterações neuropsicológicas em dependentes de cocaína
• Beneficiário: Sergio Nicastri
• Modalidade de apoio: Auxílio à Pesquisa - Regular