Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study

Autor(es)

Duarte, Poliana Mendes ^[1] ; Feres, Magda ^[1] ; Smeili Yassine, Lina Lameh ^[1] ; Silva Soares, Geisla Mary ^[2] ; Miranda, Tamires Szeremeske ^[1] ; Faveri, Marcelo ^[1] ; Retamal-Valdes, Belen ^[1] ; Figueiredo, Luciene Cristina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil

^[2] Univ Fed Parana, Dept Stomatol, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 45, n. 11, p. 1326-1335, NOV 2018.
• Citações Web of Science: 0

Resumo

Aim To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX). Material and Methods Results Diabetic and nondiabetic subjects with severe periodontitis received SRP + MTZ (400 mg/thrice a day {[}TID]) + AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by checkerboard DNA-DNA hybridization for 40 bacterial species. Subjects were monitored at baseline, 3, 6 and 12 months post-therapy. Twenty-nine type 2 diabetics and 29 non-diabetic subjects participated of this study. Of the non-diabetics and diabetics, 68.9% and 75.9%, respectively, reached the clinical endpoint for treatment (<= 4 sites with probing depth {[}PD] >= 5 mm) at 1 year post-therapy (p > 0.05). The diabetic group presented lower mean clinical attachment gain from baseline to 1 year post-therapy and higher mean proportions of the red and orange complexes than the non-diabetic group (p < 0.05). Conclusions Non-diabetic subjects with severe periodontitis did not respond better than type 2 diabetic subjects to the treatment protocol of SRP + MTZ + AMX, both in terms of achieving the clinical endpoint for treatment and of PD improvement. Diabetic subjects exhibited a slightly worse microbiological response and showed a healing process more associated with gingival recession than the non-diabetics. (AU)

• Processo FAPESP: 11/14872-4 - Metronidazol e amoxicilina sistêmicos adjunto à raspagem e alisamento radicular no tratamento de periodontite crônica em diabéticos tipo 2: avaliação clínica, glicêmica e microbiológica.
• Beneficiário: Tamires Szeremeske de Miranda
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/55291-9 - Associação de antibioticoterapia e do controle químico da placa supragengival ao tratamento periodontal mecânico: avaliação clínica e microbiológica
• Beneficiário: Luciene Cristina de Figueiredo
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/01072-5 - Metronidazol e amoxicilina sistêmicos adjunto à raspagem e alisamento radicular no tratamento de periodontite crônica em diabéticos tipo 2: avaliações clínicas, glicêmicas e microbiológicas
• Beneficiário: Poliana Mendes Duarte
• Linha de fomento: Auxílio à Pesquisa - Regular