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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses

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Autor(es):
de Matteis, Rafael [1] ; Pereira, Guilherme L. [2] ; Casarotto, Leticia T. [2] ; Tavernaro, Anna Julia S. [2] ; Silva, V, Josineudson Augusto I. I. ; Chardulo, Luis Artur L. [3] ; Curi, Rogerio A. [3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Coll Agr & Vet Sci, Dept Anim Sci, Jaboticabal, SP - Brazil
[2] Sao Paulo State Univ UNESP, Coll Vet & Anim Sci, Dept Anim Breeding & Nutr, BR-18618970 Botucatu, SP - Brazil
[3] Silva, Josineudson Augusto I. I., V, Sao Paulo State Univ UNESP, Coll Vet & Anim Sci, Dept Anim Breeding & Nutr, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Equine Veterinary Science; v. 71, p. 75-83, DEC 2018.
Citações Web of Science: 0
Resumo

The objectives of this study were to evaluate differences between the racing and cutting lines of Quarter Horses in the allele frequencies of polymorphisms identified in the chromosomal region of the myostatin gene (MSTN, ECA18) and to analyze the association of polymorphisms in this chromosomal region with the estimated breeding values (EBVs) for racing performance, given by the maximum speed index, height at withers (HW), thoracic perimeter (TP), and body length (BL) in the racing line, and with EBVs for HW, TP, and BL in the cutting line. Genomic, phenotypic, and pedigree data from 420 horses of both sexes, registered in the Brazilian Association of Quarter Horse breeders, were used (352 of racing line and 68 of cutting line). In the genome region studied (MSTN +/- 2 Mb), 46 SNPs and one SINE (ERE1) shared among the cutting and racing lines were identified, and the allele frequencies of 32 SNPs and the one SINE differed significantly between the two lines (P < .05). Furthermore, the part of this region closest to the MSTN (+/- 1 Mb) was found to be less polymorphic in the racing line. Regarding phenotype-associated polymorphisms (unadjusted P < .05), those related to HW in the racing line are highlighted because of their large number and extensive linkage disequilibrium. In addition, these markers exhibited significantly higher frequencies of the favorable allele compared to the cutting line. (C) 2018 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 14/20207-1 - Estudo amplo de associação do genoma e resequenciamento de regiões alvo em equinos de corrida da raça Quarto de Milha
Beneficiário:Rogério Abdallah Curi
Linha de fomento: Auxílio à Pesquisa - Regular