In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model

Autor(es)

Sampaio, Aline da Graca ^{[1, 2]} ; Lacerda Gontijo, Aline Vidal ^[1] ; Araujo, Helena Marcolla ^[2] ; Koga-Ito, Cristiane Yumi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Sao Jose dos Campos Inst Sci & Technol, Grad Program, Dept Environm Engn & Oral Biopathol, Sao Jose Dos Campos - Brazil

^[2] Fed Univ Rio de Janeiro UFRJ, Inst Biomed Sci, Natl Inst Sci & Technol Mol Entomol INCT EM, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Antimicrobial Agents and Chemotherapy; v. 62, n. 12 DEC 2018.
• Citações Web of Science: 1

Resumo

The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis. (AU)

• Processo FAPESP: 16/21207-0 - Avaliação do potencial de aplicação do ácido elágico nanoencapsulado em ciclodextrina no tratamento da candidose bucal
• Beneficiário: Aline da Graça Sampaio
• Modalidade de apoio: Bolsas no Brasil - Mestrado