In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model

Sampaio, Aline da Graca; Lacerda Gontijo, Aline Vidal; Araujo, Helena Marcolla; Koga-Ito, Cristiane Yumi

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model

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Author(s):	Sampaio, Aline da Graca ^{[1, 2]} ; Lacerda Gontijo, Aline Vidal ^[1] ; Araujo, Helena Marcolla ^[2] ; Koga-Ito, Cristiane Yumi ^[1] Total Authors: 4
Affiliation:	^[1] Univ Estadual Paulista UNESP, Sao Jose dos Campos Inst Sci & Technol, Grad Program, Dept Environm Engn & Oral Biopathol, Sao Jose Dos Campos - Brazil ^[2] Fed Univ Rio de Janeiro UFRJ, Inst Biomed Sci, Natl Inst Sci & Technol Mol Entomol INCT EM, Rio De Janeiro - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	Antimicrobial Agents and Chemotherapy; v. 62, n. 12 DEC 2018.
Web of Science Citations:	1
Abstract
The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis. (AU)

FAPESP's process:	16/21207-0 - Evaluation of application potential of ellagic acid nanoencapsuled in cyclodextrin for the treatment of oral candidosis
Grantee:	Aline da Graça Sampaio
Support Opportunities:	Scholarships in Brazil - Master

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