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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study

Texto completo
Autor(es):
Monico-Neto, Marcos [1] ; Moreira Antunes, Hanna Karen [1, 2] ; Thomatieli dos Santos, Ronaldo Vagner [1, 2] ; D'Almeida, Vania [1] ; Lino de Souza, Altay Alves [1] ; Azeredo Bittencourt, Lia Rita [1] ; Tufik, Sergio [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Santos - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: European Respiratory Journal; v. 52, n. 4 OCT 1 2018.
Citações Web of Science: 3
Resumo

Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities. In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8-9-year follow-up study. We analysed data of 658 volunteers from the Sao Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20-80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile. Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296-0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252-0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(B)=0.720; p=0.001), interleukin-6 (exp(B)=0.991; p=0.03), insulin (exp(B)=0.982; p=0.03), triglycerides (exp(B)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(B)<= 0.946; p<0.024), quantitative insulin sensitivity check index (exp(B)=992.4; p<0.001) and mean arterial pressure (exp(B)=0.987; p=0.001). Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 13/00152-5 - Efeito do exercício físico resistido no músculo esquelético e cardíaco de ratos Wistar submetidos a privação de sono paradoxal
Beneficiário:Hanna Karen Moreira Antunes
Linha de fomento: Auxílio à Pesquisa - Regular