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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study

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Monico-Neto, Marcos [1] ; Moreira Antunes, Hanna Karen [1, 2] ; Thomatieli dos Santos, Ronaldo Vagner [1, 2] ; D'Almeida, Vania [1] ; Lino de Souza, Altay Alves [1] ; Azeredo Bittencourt, Lia Rita [1] ; Tufik, Sergio [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Santos - Brazil
Total Affiliations: 2
Document type: Journal article
Source: European Respiratory Journal; v. 52, n. 4 OCT 1 2018.
Web of Science Citations: 4

Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities. In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8-9-year follow-up study. We analysed data of 658 volunteers from the Sao Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20-80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile. Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296-0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252-0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(B)=0.720; p=0.001), interleukin-6 (exp(B)=0.991; p=0.03), insulin (exp(B)=0.982; p=0.03), triglycerides (exp(B)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(B)<= 0.946; p<0.024), quantitative insulin sensitivity check index (exp(B)=992.4; p<0.001) and mean arterial pressure (exp(B)=0.987; p=0.001). Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/00152-5 - Effect of resistance exercise in cardiac and skeletal muscle of Wistar rats submitted to paradoxical sleep deprivation
Grantee:Hanna Karen Moreira Antunes
Support type: Regular Research Grants