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Effects of excessive daytime sleepiness or insomnia associated with obstructive sleep apnea on the cardiovascular risk: a prospective longitudinal population-based study

Grant number: 15/19136-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2016
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Monica Levy Andersen
Grantee:Lenise Jihe Kim
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


In the last 3 decades, the prevalence of sleep disorders and sleep complaints have been increasing, including respiratory events, difficulties in falling asleep and in the sleep maintenance, and excessive daytime sleepiness (EDS). Obstructive sleep apnea (OSA), insomnia, and EDS are risk factors of cardiovascular outcomes. Nevertheless, the effects of the association among these sleep disturbances are still divergent and the methodological limitations of the studies reduce the validity of the existing findings. Our research aims to investigate the relationship between EDS or insomnia associated with OSA in the risk of cardiovascular outcomes. This study consists in a large prospective longitudinal population-based study after 8 years of patients follow-up. To evaluate the isolated effect of EDS and when associated with OSA on the cardiovascular risk, the participants from the population-based study will be distributed in the groups no-OSA without EDS, no-OSA with EDS, OSA without EDS, and OSA with EDS. To evaluate the isolated effect of insomnia and when associated with OSA on the cardiovascular risk, the participants will be distributed in the groups no-OSA without insomnia, no-OSA with insomnia, OSA without insomnia, and OSA with insomnia. The outcomes that will be evaluate comprise the mortality rate, frequency of cardiovascular events, and the profile of cardiovascular risk factors. We expect that the findings of our study indicate that, besides the isolated effect, the OSA associated with EDS or insomnia potentiates the negative effects of OSA on patients' health. This research could provide new perspectives of diagnostic and therapeutic approaches for sleep disorders, aiming to decrease the risk of cardiovascular diseases and to improve the individuals' quality of life.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, DANIELA LEITE; DOKKEDAL-SILVA, VINICIUS; FERNANDES, GUILHERME LUIZ; KIM, LENISE JIHE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 17, n. 12, p. 2439-2449, DEC 1 2021. Web of Science Citations: 0.
MAIA PALHANO, ANA CLARA; KIM, LENISE JIHE; MOREIRA, GUSTAVO A.; SANTOS COELHO, FERNANDO MORGADINHO; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Narcolepsy, Precocious Puberty and Obesity in the Pediatric Population: a Literature Review. PEDIATRIC ENDOCRINOLOGY REVIEWS PER, v. 16, n. 2, p. 266-274, DEC 2018. Web of Science Citations: 1.
NOZOE, KAREN TIEME; KIM, LENISE JIHE; POLESEL, DANIEL NINELLO; HIROTSU, CAMILA; DE SOUZA, ALTAY LINO; HACHUL, HELENA; TUFIK, SERGIO BRASIL; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; MOREIRA, GUSTAVO ANTONIO. Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers. Sleep Medicine, v. 32, p. 114-121, APR 2017. Web of Science Citations: 1.
SOTERIO-PIRES, J. H.; HIROTSU, C.; KIM, L. J.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L. The interaction between erectile dysfunction complaints and depression in men: a cross-sectional study about sleep, hormones and cl uality of life. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 29, n. 2, p. 70-75, MAR-APR 2017. Web of Science Citations: 9.

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