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Identification of the main associated factors with Obstructive Sleep Apnea Syndrome in women

Grant number: 13/14945-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2013
Effective date (End): May 31, 2015
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Helena Hachul de Campos
Grantee:Daniel Ninello Polesel
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The natural aging process of women is accompanied by a transition of reproductive cycles and a series of negative consequences to women' health, being the increased incidence of sleep-disordered breathing one of the most relevant clinical context. Studies indicate that obstructive sleep apnea syndrome (OSAS) is a sleep disorder highly prevalent in the population and is associated with negative health outcomes, such as daytime sleepiness, cognitive impairment, immune, cardiovascular and metabolic dysfunction. In women, the menopausal transition has been associated with the development of OSAS. Anthropometrical factors, obesity-related can favor the development of OSAS or it's worsening. Thus, given the repercussions caused by OSAS in women' health, this project aims to investigate the factors associated with this sleep disorder in women. We will be analyze anthropometric and biochemical data and parameters obtained by complete polysomnography of 574 women aged 20-80 years from a representative sample of the city of São Paulo. The identification of the risk factors can be able to help the clinical practice to minimize magnitude of injurious effects to the body resulting from OSAS in women.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
POLESEL, DANIEL NINELLO; NOZOE, KAREN TIEME; TUFIK, SERGIO BRASIL; BEZERRA, ANDREIA GOMES; BECHERE FERNANDES, MARIA TERESA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; HACHUL, HELENA. Gender differences in the application of anthropometric measures for evaluation of obstructive sleep apnea. SLEEP SCIENCE, v. 12, n. 1, p. 2-9, 2019. Web of Science Citations: 0.
POLESEL, DANIEL NINELLO; NOZOE, KAREN T.; SANCHEZ, ZILA M.; PRADO, MARIANGELA C. O.; BITTENCOURT, LIA R.; TUFIK, SERGIO; ANDERSEN, MONICA L.; HACHUL, HELENA. The Follicle-Stimulating Hormone as Best Classifier for Diagnosis of Natural Menopause. JOURNAL OF GYNECOLOGIC SURGERY, v. 33, n. 6, p. 236-242, DEC 2017. Web of Science Citations: 1.
POLESEL, DANIEL N.; HIROTSU, CAMILA; NOZOE, KAREN T.; BOIN, ANDRE C.; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA L.; HACHUL, HELENA. Waist circumference and postmenopause stages as the main associated factors for sleep apnea in women: a cross-sectional population-based study. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 22, n. 8, p. 835-844, AUG 2015. Web of Science Citations: 20.

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