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Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO

Grant number: 14/15259-2
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Sergio Tufik
Grantee:Camila Hirotsu
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


In 2007, the cross-sectional study called EPISONO revealed the sleep pattern of a representative sample from the city of São Paulo, showing a high prevalence of sleep disorders such as obstructive sleep apnea and insomnia. To better clarify the burden that sleep disturbances lead to society, longitudinal studies have demonstrated a possible link between sleep and the risk of hypertension, diabetes, coronary heart disease, stroke, cancer and mortality. However, there are few studies, most with distinct populations and lacking a prospective assessment of sleep objectively. Therefore, the aim of this project is to evaluate prospectively the cohort originated by EPISONO study through investigation of the prognosis and frequency of complications among individuals who had sleep disturbances, changes in classification of the severity of these disorders and the incidence of new cases. All volunteers originally included in the baseline study will be invited to visit the Sleep Institute to answer the questionnaires and perform the polysomnography, actigraphy, blood collection for clinical analysis, blood pressure measurement, body assessment and pulmonary function. Statistical methods to evaluate estimates of variability and precision as well as the interval will employ methods of Taylor series linearization to avoid underestimation bias. For comparison between the baseline and follow up studies, technical analysis of pseudo-panels will be used, considering that the same population is studied.

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Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEMPAKU, PRISCILA; HIROTSU, CAMILA; MAZZOTTI, DIEGO; XAVIER, GABRIELA; MAURYA, PAWAN; BRIELZKE, ELISA; BELANGERO, SINTIA; POYARES, DALVA; BITTENCOURT, LIA; TUFIK, SERGIO. Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 14, n. 12, p. 2037-2045, . (15/17549-0, 14/15259-2)
HIROTSU, CAMILA; ALBUQUERQUE, RACHEL G.; NOGUEIRA, HELOISA; HACHUL, HELENA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA L.. The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence. BRAIN BEHAVIOR AND IMMUNITY, v. 59, p. 211-218, . (14/15259-2, 14/27329-5)
DE OLIVEIRA, DANIELA LEITE; HIROTSU, CAMILA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. The interfaces between vitamin D, sleep and pain. Journal of Endocrinology, v. 234, n. 1, p. R23-R36, . (16/02205-7, 14/15259-2)
TEMPAKU, PRISCILA F.; HIROTSU, CAMILA; SILVA, VINICIUS D.; TUFIK, SERGIO. Letter to the editor: Sleep as a contributing factor in the relationship between depression and cell aging. JOURNAL OF PSYCHIATRIC RESEARCH, v. 82, p. 48-49, . (15/17549-0, 14/15259-2)
PEDRONI, MATHEUS NEGRAO; HIROTSU, CAMILA; PORRO, ADRIANA MARIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. The role of sleep in pemphigus: a review of mechanisms and perspectives. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 309, n. 8, p. 659-664, . (16/16703-9, 14/15259-2)
PIOVEZAN, RONALDO D.; HIROTSU, CAMILA; FERES, MARCIA C.; CINTRA, FATIMA D.; ANDERSEN, MONICA L.; TUFIK, SERGIO; POYARES, DALVA. Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency. PLoS One, v. 12, n. 7, . (98/14303-3, 14/15259-2)
ALVARENGA, TATHIANA A.; HIROTSU, CAMILA; MAZARO-COSTA, RENATA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Impairment of male reproductive function after sleep deprivation. Fertility and Sterility, v. 103, n. 5, p. 1355+, . (12/05396-7, 14/15259-2, 11/12325-6)
TEMPAKU, PRISCILA FARIAS; MAZZOTTI, DIEGO ROBLES; HIROTSU, CAMILA; ANDERSEN, MONICA LEVY; XAVIER, GABRIELA; MAURYA, PAWAN KUMAR; RIZZO, LUCAS BORTOLOTTO; BRIETZKE, ELISA; BELANGERO, SINTIA IOLE; BITTENCOURT, LIA; et al. The effect of the severity of obstructive sleep apnea syndrome on telomere length. ONCOTARGET, v. 7, n. 43, p. 69216-69224, . (15/17549-0, 14/15259-2)
KIM, LENISE JIHE; COELHO, FERNANDO MORGADINHO; HIROTSU, CAMILA; ARAUJO, PAULA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 11, n. 12, p. 1377-1384, . (14/10255-9, 13/14420-1, 14/15259-2)
HIROTSU, CAMILA; PEDRONI, MATHEUS NEGRAO; BERRO, LAIS FERNANDA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats. SCIENTIFIC REPORTS, v. 8, . (14/15259-2)
HIROTSU, CAMILA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Interactions between sleep, stress, and metabolism: From physiological to pathological conditions. SLEEP SCIENCE, v. 8, n. 3, p. 143-152, . (14/15259-2)
ALBUQUERQUE, RACHEL GIMENES; OKAZAKI, KEITY MEY; HIROTSU, CAMILA; TOMIMORI, JANE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep, Hansen's disease and the immune system - A not so harmonic triad. Medical Hypotheses, v. 84, n. 5, p. 456-459, . (14/00923-4, 12/21794-2, 14/15259-2)
FRANGE, C.; HIROTSU, C.; HACHUL, H.; PIRES, J. S.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L.. Musculoskeletal pain and the reproductive life stage in women: is there a relationship?. CLIMACTERIC, v. 19, n. 3, p. 279-284, . (15/02036-8, 14/18722-5, 14/15259-2)
HIROTSU, C.; SOTERIO-PIRES, J. H.; TUFIK, S.; ANDERSEN, M. L.. Sleep disturbance and sexual dysfunction in postmenopausal women. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 29, n. 3, p. 126, . (15/02036-8, 14/15259-2)
HACHUL, HELENA; FRANGE, CRISTINA; BEZERRA, ANDREIA GOMES; HIROTSU, CAMILA; PIRES, GABRIEL NATAN; ANDERSEN, MONICA LEVY; BITTENCOURT, LIA; TUFIK, SERGIO. The effect of menopause on objective sleep parameters: Data from an epidemiologic study in Sao Paulo, Brazil. MATURITAS, v. 80, n. 2, p. 170-178, . (14/15259-2)
ALBUQUERQUE, RACHEL GIMENES; DIAS DA ROCHA, MARCO ALEXANDRE; HIROTSU, CAMILA; HACHUL, HELENA; BAGATIN, EDILEIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. A randomized comparative trial of a combined oral contraceptive and azelaic acid to assess their effect on sleep quality in adult female acne patients. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 307, n. 10, p. 905-915, . (12/21794-2, 14/00923-4, 14/15259-2)
HIROTSU, CAMILA; NOGUEIRA, HELOISA; ALBUQUERQUE, RACHEL G.; TOMIMORI, JANE; TUFIK, SERGIO; ANDERSEN, MONICA L.. The bidirectional interactions between psoriasis and obstructive sleep apnea. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 54, n. 12, p. 1352-1358, . (12/21794-2, 14/00923-4, 14/15259-2)
HIROTSU, CAMILA; HABA-RUBIO, JOSE; TOGEIRO, SONIA M.; MARQUES-VIDAL, PEDRO; DRAGER, LUCIANO F.; VOLLENWEIDER, PETER; WAEBER, GERARD; BITTENCOURT, LIA; TUFIK, SERGIO; HEINZER, RAPHAEL. Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study. European Respiratory Journal, v. 52, n. 5, . (14/15259-2)

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