Burnt sugarcane harvesting work: effects on pulmonary and systemic inflammatory markers

Autor(es)

Leite, Marceli Rocha ^[1] ; Trevisan Zanetta, Dirce Maria ^[2] ; Antonangelo, Leila ^[3] ; Marcal, Lia Junqueira ^[3] ; Ramos, Dionei ^[4] ; Burdmann, Emmanuel Almeida ^[5] ; Santos, Ubiratan Paula ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Coracao, Hosp Clin HCFMUSP, Div Pneumol, Fac Med, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Epidemiol, Publ Hlth Sch, Sao Paulo - Brazil

^[3] Univ Sao Paulo, LIM 03, Dept Patol, Fac Med FMUSP, Sao Paulo - Brazil

^[4] Univ Estadual Paulista, Dept Physiotherapy, Campus Presidente Prudente, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Hosp Clin HCFMUSP, Div Nefrol, Fac Med, LIM 12, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INHALATION TOXICOLOGY; v. 30, n. 6, p. 205-212, 2018.
• Citações Web of Science: 0

Resumo

Objective: To evaluate the effects of burnt sugarcane harvesting on the plasmatic and urinary concentrations of the club cell secretory protein (CC16) and inflammatory systemic biomarkers in a group of sugarcane cutters.Methods: Seventy-eight sugar cane workers were evaluated. The plasmatic and urinary concentrations of CC16, a pulmonary damage marker and inflammatory systemic biomarkers were collected at three time points: before, three months after and six months after the onset of the burnt sugarcane harvesting period. All evaluations were performed at approximate to 7 am, before the daily work shift. In the three-month evaluation, a post-work shift assessment (acute effect) was also performed.Results: The age of the workers was 37.911.0years. The PM2.5 concentrations were 27.0 (23.0-33.0) and 101.0 (31.0-139.5) mu g/m(3) in the pre harvest and harvest periods, respectively (p<.001). Burnt sugarcane harvesting was associated with a reduction, throughout the work during burnt sugarcane harvesting (subchronic effect), in plasmatic and urinary CC16 concentrations. Acutely, there was a decrease in plasmatic concentrations. There were acute and subchronic increases in inflammatory markers (neutrophils, monocytes) and muscle damage markers (CK and LDH) and a decrease in red blood cells.Conclusions: Harvesting of burnt sugarcane was associated with acute and subchronic reductions in the plasmatic and urinary concentrations of CC16 protein and changes in systemic inflammatory markers. (AU)

• Processo FAPESP: 14/19286-4 - Indivíduos com alto risco para desenvolvimento de injúria renal aguda em contextos clínicos relevantes: estudo prospectivo sobre aspectos epidemiológicos, diagnósticos e prognósticos
• Beneficiário: Emmanuel de Almeida Burdmann
• Modalidade de apoio: Auxílio à Pesquisa - Temático