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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Exposure to aluminum, aluminum plus manganese and acid pH triggers different antioxidant responses in gills and liver of Astyanax altiparanae (Teleostei: Characiformes: Characidae) males

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Autor(es):
Abdalla, R. P. [1] ; Kida, B. M. S. [1] ; Pinheiro, J. P. S. [1] ; Oliveira, L. F. [2] ; Martinez, C. B. F. [2] ; Moreira, R. G. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Lab Metab & Reprod Organismos Aquat, Rua Matao, Travessa 14, 321, Sao Paulo, SP - Brazil
[2] Univ Estadual Londrina, Dept Ciencias Fisiol, Lab Ecofisiol Anim, Londrina, Parana - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 215, p. 33-40, JAN 2019.
Citações Web of Science: 2
Resumo

Exposure to aluminum (Al) and aluminum + manganese (Mn) can trigger an increase in reactive oxygen species (ROS) and modify the activity of oxidative defense enzymes. This study investigated whether exposure to Al and Al + Mn at acid pH for 24 and 96 h causes oxidative stress evidenced by antioxidants and oxidative damage in the gills and liver of sexually mature Astyanax altiparanae males. The fish were subsequently immersed in metal-free water for 24 and 96 h to see whether they recovered from the effects of these metals. Exposure to an acid pH boosted the activity of gill superoxide dismutase (SOD) at 96 h and the fish did not recover when immersed for the same period in water at neutral pH. Exposure to Al increased glutathione (GSH) levels (24 h) in the gills, returning to control levels during the recovery period, showing the efficiency of the antioxidant system in preventing lipid peroxidation of the gills and liver. Mn did not modify the activity of the enzymes studied, but did trigger late hepatic lipid peroxidation during the recovery period. The group exposed to Al + Mn exhibited several alterations, including increased concentration of GSH, as well as higher GPx and GR activity in the gills. Despite the defensive responses triggered by acute exposure, during the recovery period there were alterations in catalase (96 h) and an increase in hepatic metallothionein (24 h), but this did not prevent hepatic lipid peroxidation. Al and Al + Mn produced different effects, and the timing of enzymatic and non-enzymatic antioxidant defenses also differed. (AU)

Processo FAPESP: 08/57687-0 - Effects of global climate change of the Brazilian fauna: a conservation physiology approach
Beneficiário:Carlos Arturo Navas Iannini
Linha de fomento: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Temático
Processo FAPESP: 12/50918-1 - Desempenho comportamental em vertebrados ectotermicos: respostas as mudanças ambientais
Beneficiário:Carlos Arturo Navas Iannini
Linha de fomento: Auxílio à Pesquisa - Regular