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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exposure to aluminum, aluminum plus manganese and acid pH triggers different antioxidant responses in gills and liver of Astyanax altiparanae (Teleostei: Characiformes: Characidae) males

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Author(s):
Abdalla, R. P. [1] ; Kida, B. M. S. [1] ; Pinheiro, J. P. S. [1] ; Oliveira, L. F. [2] ; Martinez, C. B. F. [2] ; Moreira, R. G. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Lab Metab & Reprod Organismos Aquat, Rua Matao, Travessa 14, 321, Sao Paulo, SP - Brazil
[2] Univ Estadual Londrina, Dept Ciencias Fisiol, Lab Ecofisiol Anim, Londrina, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 215, p. 33-40, JAN 2019.
Web of Science Citations: 2
Abstract

Exposure to aluminum (Al) and aluminum + manganese (Mn) can trigger an increase in reactive oxygen species (ROS) and modify the activity of oxidative defense enzymes. This study investigated whether exposure to Al and Al + Mn at acid pH for 24 and 96 h causes oxidative stress evidenced by antioxidants and oxidative damage in the gills and liver of sexually mature Astyanax altiparanae males. The fish were subsequently immersed in metal-free water for 24 and 96 h to see whether they recovered from the effects of these metals. Exposure to an acid pH boosted the activity of gill superoxide dismutase (SOD) at 96 h and the fish did not recover when immersed for the same period in water at neutral pH. Exposure to Al increased glutathione (GSH) levels (24 h) in the gills, returning to control levels during the recovery period, showing the efficiency of the antioxidant system in preventing lipid peroxidation of the gills and liver. Mn did not modify the activity of the enzymes studied, but did trigger late hepatic lipid peroxidation during the recovery period. The group exposed to Al + Mn exhibited several alterations, including increased concentration of GSH, as well as higher GPx and GR activity in the gills. Despite the defensive responses triggered by acute exposure, during the recovery period there were alterations in catalase (96 h) and an increase in hepatic metallothionein (24 h), but this did not prevent hepatic lipid peroxidation. Al and Al + Mn produced different effects, and the timing of enzymatic and non-enzymatic antioxidant defenses also differed. (AU)

FAPESP's process: 12/50918-1 - Behavioral performance in ectothermic vertebrates: responses to environmental change
Grantee:Carlos Arturo Navas Iannini
Support type: Regular Research Grants
FAPESP's process: 08/57687-0 - Effects of global climate change of the Brazilian fauna: a conservation physiology approach
Grantee:Carlos Arturo Navas Iannini
Support type: Research Program on Global Climate Change - Thematic Grants