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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application

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Autor(es):
Bronze-Uhle, Erika S. [1] ; Dias, Leonardo F. G. [1] ; Trino, Luciana D. [1] ; Matos, Adriana A. [2] ; de Oliveira, Rodrigo C. [2] ; Lisboa-Filho, Paulo N. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Sch Sci, Dept Phys, Bauru, SP - Brazil
[2] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Bauru, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: SURFACE & COATINGS TECHNOLOGY; v. 357, p. 36-47, JAN 15 2019.
Citações Web of Science: 0
Resumo

Titanium and its alloys have been routinely used to replace bone and teeth. This success is mainly due to their remarkable clinical response, mechanical properties, chemical stability and appropriate biocompatibility associated to a titanium dioxide (TiO2) layer. Chemically, the TiO2 surface is mostly terminated by -OH groups. An increased amount of reactive -OH groups can be obtained by UV radiation treatment on TiO2 surface, which can be readily functionalized with bifunctional organic molecules. Among the several types of organic molecules available for reaction with -OH groups, bisphosphonates (BP) have been associated with a positive effect on new bone formation. In this way, the present contribution aims at giving an overview study from the physicochemical properties of two distinct BP (alendronate and risedronate), immobilized on the titanium surface containing hydroxylated TiO2 film by UV radiation. Surface properties such as contact angle, surface free energy and topography/roughness were evaluated. In addition, biocompatibility and mineralization tests performed with osteoblastic-like cells are presented to evaluate the potential of these functional materials to be applied in the dentistry and orthopedics fields. The results suggest that the UV treatment increased the surface wettability and allowed an oriented immobilization of BP. In addition, the BP functionalized surfaces exhibited high viability and mineralization of pre-osteoblast cells. Therefore, these compounds emerge as a potential treatment on implants surfaces. (AU)

Processo FAPESP: 14/01713-3 - Funcionalização de superfícies e estudo de adsorção em óxidos metálicos
Beneficiário:Luciana Daniele Trino
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/20471-0 - Filmes finos de óxidos metálicos funcionalizados para estudo da adsorção de proteínas
Beneficiário:Paulo Noronha Lisboa Filho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/11183-7 - Deposição e funcionalização de superfícies de filmes finos de TiO2 preparados por spin coating
Beneficiário:Leonardo Francisco Gonçalves Dias
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 17/15035-5 - Adsorção de bisfosfonatos e proteínas em superfícies de TiO2 para implantes ósseos
Beneficiário:Paulo Noronha Lisboa Filho
Linha de fomento: Auxílio à Pesquisa - Regular