| Full text | |
| Author(s): |
Bronze-Uhle, Erika S.
[1]
;
Dias, Leonardo F. G.
[1]
;
Trino, Luciana D.
[1]
;
Matos, Adriana A.
[2]
;
de Oliveira, Rodrigo C.
[2]
;
Lisboa-Filho, Paulo N.
[1]
Total Authors: 6
|
| Affiliation: | [1] UNESP Sao Paulo State Univ, Sch Sci, Dept Phys, Bauru, SP - Brazil
[2] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Bauru, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SURFACE & COATINGS TECHNOLOGY; v. 357, p. 36-47, JAN 15 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Titanium and its alloys have been routinely used to replace bone and teeth. This success is mainly due to their remarkable clinical response, mechanical properties, chemical stability and appropriate biocompatibility associated to a titanium dioxide (TiO2) layer. Chemically, the TiO2 surface is mostly terminated by -OH groups. An increased amount of reactive -OH groups can be obtained by UV radiation treatment on TiO2 surface, which can be readily functionalized with bifunctional organic molecules. Among the several types of organic molecules available for reaction with -OH groups, bisphosphonates (BP) have been associated with a positive effect on new bone formation. In this way, the present contribution aims at giving an overview study from the physicochemical properties of two distinct BP (alendronate and risedronate), immobilized on the titanium surface containing hydroxylated TiO2 film by UV radiation. Surface properties such as contact angle, surface free energy and topography/roughness were evaluated. In addition, biocompatibility and mineralization tests performed with osteoblastic-like cells are presented to evaluate the potential of these functional materials to be applied in the dentistry and orthopedics fields. The results suggest that the UV treatment increased the surface wettability and allowed an oriented immobilization of BP. In addition, the BP functionalized surfaces exhibited high viability and mineralization of pre-osteoblast cells. Therefore, these compounds emerge as a potential treatment on implants surfaces. (AU) | |
| FAPESP's process: | 14/01713-3 - Functionalization and adsorption studies on thin oxide films |
| Grantee: | Luciana Daniele Trino Albano |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/20471-0 - Functionalized metal oxides thin films for the study of protein adsorption |
| Grantee: | Paulo Noronha Lisboa Filho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/11183-7 - Deposition and functionalization of TiO2 thin films surface |
| Grantee: | Leonardo Francisco Gonçalves Dias |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/15035-5 - Adsorption of bisphosphonates and proteins on TiO2 surfaces for bone implants |
| Grantee: | Paulo Noronha Lisboa Filho |
| Support Opportunities: | Regular Research Grants |