Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats

Autor(es)

Ceron, Carla S. ^[1] ; do Vale, Gabriel T. ^{[2, 1]} ; Simplicio, Janaina A. ^{[2, 1]} ; Passaglia, Patricia ^[1] ; Ricci, Sthefany T. ^[1] ; Tirapelli, Carlos R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, DEPCH, Lab Fannacol, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DATA IN BRIEF; v. 11, p. 111-116, APR 2017.
• Citações Web of Science: 3

Resumo

We describe the effects of losartan, a selective AT(1) receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled ``Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress{''} (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) {[}1]. I Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aorta. Losartan prevented ethanol-induced increase in the aortic expression of nNOS. Neither ethanol nor losartan affected superoxide dismutase (SOD) or catalase (CAT) activities in the rat aorta. Treatment with ethanol increased the contraction induced by phenylephrine in both endothelium-intact and endothelium-denuded aortas and these responses were prevented by losartan. Conversely, neither ethanol nor losartan affected the endothelium-dependent relaxation induced by acetylcholine. (C) 2017 The Authors. Published by Elsevier Inc. (AU)

• Processo FAPESP: 10/05815-4 - Avaliação da participação da angiotensina II nos efeitos cardiovasculares induzidos pelo consumo agudo de etanol
• Beneficiário: Carlos Renato Tirapelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular