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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats

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Author(s):
Ceron, Carla S. [1] ; do Vale, Gabriel T. [2, 1] ; Simplicio, Janaina A. [2, 1] ; Passaglia, Patricia [1] ; Ricci, Sthefany T. [1] ; Tirapelli, Carlos R. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, DEPCH, Lab Fannacol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: DATA IN BRIEF; v. 11, p. 111-116, APR 2017.
Web of Science Citations: 3
Abstract

We describe the effects of losartan, a selective AT(1) receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled ``Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress{''} (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) {[}1]. I Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aorta. Losartan prevented ethanol-induced increase in the aortic expression of nNOS. Neither ethanol nor losartan affected superoxide dismutase (SOD) or catalase (CAT) activities in the rat aorta. Treatment with ethanol increased the contraction induced by phenylephrine in both endothelium-intact and endothelium-denuded aortas and these responses were prevented by losartan. Conversely, neither ethanol nor losartan affected the endothelium-dependent relaxation induced by acetylcholine. (C) 2017 The Authors. Published by Elsevier Inc. (AU)

FAPESP's process: 10/05815-4 - Assessment of the role of angiotensin II in the cardiovascular effects induced by acute ethanol consumption
Grantee:Carlos Renato Tirapelli
Support Opportunities: Regular Research Grants