Microbiota and Type 2 immune responses

Autor(es)

McCoy, Kathy D. ^[1] ; Ignacio, Aline ^{[1, 2]} ; Geuking, Markus B. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1 - Canada

^[2] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, Lab Transplantat Immunobiol, Sao Paulo, SP - Brazil

^[3] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, Calgary, AB T2N 4N1 - Canada

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT OPINION IN IMMUNOLOGY; v. 54, p. 20-27, OCT 2018.
• Citações Web of Science: 8

Resumo

The trillions of microbes that colonize mucosal surfaces are critical for educating the immune system and microbial-derived signals continually shape and set the tone of immune responses. Although Type 2 immune responses are important for mediating protection from helminth infection they also underlie atopy and allergy. Microbes modulate Type 2 immune responses through effects on Type 2 cytokines, dendritic cells and regulatory T cells. Microbial colonization in the gut, the lung and the skin during an early and critical time period in immune development appears to be of particular importance for tolerance induction and regulation of aberrant Type 2 immune responses. This is illustrated by studies showing microbial alterations in early life that are associated with allergies later in life. (AU)

• Processo FAPESP: 16/15882-7 - Investigação da interação dinâmica entre eosinófilos e células dendríticas em resposta a microbiota intestinal.
• Beneficiário: Aline Ignacio Silvestre da Silva
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado