Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO2 chemoreflex

Autor(es)

Cabral Rodrigues, Laisa Tais ^[1] ; da Silva, Eliandra Nunes ^[1] ; Horta-Junior, Jose de Anchieta C. ^[2] ; Gargaglioni, Luciane H. ^[3] ; Dias, Mirela B. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Physiol, Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Anat, Botucatu, SP - Brazil

^[3] Sao Paulo State Univ FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Respiratory Physiology & Neurobiology; v. 260, p. 122-130, FEB 2019.
• Citações Web of Science: 1

Resumo

It has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal state variations of the central chemoreflex, but the mechanisms that underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs on metabotropic receptors in the LH/PFA modulate the hypercapnic ventilatory response. We studied the effects of microinjection of a glutamate metabotropic receptor (mGluR) antagonist (( +)-alpha-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and a selective Group II/III mGluR antagonist ((2S)-2-Amino-2-{[}(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; LY341495; 5 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO2, during wakefulness and sleep, in the dark and light periods of the diurnal cycle. Microinjection of MCPG and LY341495 increased the hypercapnic ventilatory response in both the light and the dark period during wakefulness, but not during sleep, (p < 0.001). Our data suggest that glutamate, acting on Group II/III metabotropic receptors in the LH/PFA, exerts an inhibitory modulation of the hypercapnic ventilatory response in awake rats. (AU)

• Processo FAPESP: 14/17862-8 - O papel dos receptores metabotrópicos glutamatérgicos no hipotálamo lateral e área perifornicial (LH/PFA) no controle das variações diárias das respostas ventilatórias promovidas pela ativação do quimiorreflexo central
• Beneficiário: Laísa Taís Cabral Rodrigues Xavier
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/04216-8 - Mecanismos neurais envolvidos com as variações diárias do controle do quimiorreflexo central
• Beneficiário: Mirela Barros Dias
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/05174-5 - O papel dos receptores metabotrópicos glutamatérgicos do Grupo II no hipotálamo lateral e área perifornicial (LH/PFA) no controle das variações diárias das respostas ventilatórias promovidas pela ativação do quimiorreflexo central
• Beneficiário: Laísa Taís Cabral Rodrigues Xavier
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica