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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO2 chemoreflex

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Author(s):
Cabral Rodrigues, Laisa Tais [1] ; da Silva, Eliandra Nunes [1] ; Horta-Junior, Jose de Anchieta C. [2] ; Gargaglioni, Luciane H. [3] ; Dias, Mirela B. [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Physiol, Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Anat, Botucatu, SP - Brazil
[3] Sao Paulo State Univ FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 260, p. 122-130, FEB 2019.
Web of Science Citations: 1
Abstract

It has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal state variations of the central chemoreflex, but the mechanisms that underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs on metabotropic receptors in the LH/PFA modulate the hypercapnic ventilatory response. We studied the effects of microinjection of a glutamate metabotropic receptor (mGluR) antagonist (( +)-alpha-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and a selective Group II/III mGluR antagonist ((2S)-2-Amino-2-{[}(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; LY341495; 5 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO2, during wakefulness and sleep, in the dark and light periods of the diurnal cycle. Microinjection of MCPG and LY341495 increased the hypercapnic ventilatory response in both the light and the dark period during wakefulness, but not during sleep, (p < 0.001). Our data suggest that glutamate, acting on Group II/III metabotropic receptors in the LH/PFA, exerts an inhibitory modulation of the hypercapnic ventilatory response in awake rats. (AU)

FAPESP's process: 14/17862-8 - Glutamatergic metabotropic receptors role in lateral hypothalamus and perifornicial area (LH/PFA) in daily variations control of ventilatory responses promoted by central chemoreflex activation
Grantee:Laísa Taís Cabral Rodrigues Xavier
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/04216-8 - Neural mechanisms involved in the diurnal variation of the central chemoreflex control
Grantee:Mirela Barros Dias
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 16/05174-5 - Group II glutamatergic metabotropic receptors role in lateral hypothalamus and perifornicial area (LH/PFA) in daily variations control of ventilatory responses promoted by central chemoreflex activation
Grantee:Laísa Taís Cabral Rodrigues Xavier
Support Opportunities: Scholarships in Brazil - Scientific Initiation