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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control

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Autor(es):
de Oliveira, Marcela [1] ; Duarte, Sergio Barbosa [2] ; Giacomini, Guilherme [1] ; Marques Pereira, Paulo Camara [3] ; de Souza, Lenice do Rosario [3] ; de Arruda Miranda, Jose Ricardo [1] ; de Pina, Diana Rodrigues [3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Fis & Biofis, Botucatu, SP - Brazil
[2] Ctr Brasileiro Pesquisas Fis, Dept Altas Energias, Rio De Janeiro, RJ - Brazil
[3] Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 25, FEB 14 2019.
Citações Web of Science: 0
Resumo

Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method based on chest radiography to quantify lung-involvement volume of TB acute-phase patients before and after treatment. In addition, these results were compared with indices from conventional clinical exams to show the coincidence level. Methods: A 3D lung reconstruction method using patient chest radiography was applied to quantify lung-involvement volume using retrospective examinations of 50 patients who were diagnosed with pulmonary TB and treated with two different drugs schemes. Twenty-five patients were treated with Scheme I (rifampicin, isoniazid, and pyrazinamide), whereas twenty-five patients were treated with Scheme II (rifampicin, isoniazid, pyrazinamide, and ethambutol). Acute-phase reaction: Serum exams included C-reactive protein levels, erythrocyte sedimentation rate, and albumin levels. Pulmonary function was tested posttreatment. Results: We found strong agreement between lung involvement and serum indices pre- and posttreatment. Comparison of the functional severity degree with lung involvement based on 3D image quantification for both treatment schemes found a high correlation. Conclusions: The present 3D reconstruction method produced a satisfactory agreement with the acute-phase reaction, most notably a higher significance level with the C-reactive protein. We also found a quite reasonable coincidence between the 3D reconstruction method and the degree of functional lung impairment posttreatment. The performance of the quantification method was satisfactory when comparing the two treatment schemes. Thus, the 3D reconstruction quantification method may be useful tools for monitoring TB treatment. The association with serum indices are not only inexpensive and sensitive but also may be incorporated into the assessment of patients during TB treatment. (AU)

Processo FAPESP: 15/01948-3 - Quantificação Objetiva de Fibrose/Processo Inflamatório em Pacientes com Tuberculose Pulmonar Utilizando Exames de Raios-X de Tórax.
Beneficiário:Marcela de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado