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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control

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Author(s):
de Oliveira, Marcela [1] ; Duarte, Sergio Barbosa [2] ; Giacomini, Guilherme [1] ; Marques Pereira, Paulo Camara [3] ; de Souza, Lenice do Rosario [3] ; de Arruda Miranda, Jose Ricardo [1] ; de Pina, Diana Rodrigues [3]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Fis & Biofis, Botucatu, SP - Brazil
[2] Ctr Brasileiro Pesquisas Fis, Dept Altas Energias, Rio De Janeiro, RJ - Brazil
[3] Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 25, FEB 14 2019.
Web of Science Citations: 0
Abstract

Abstract Background: Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method based on chest radiography to quantify lung-involvement volume of TB acute-phase patients before and after treatment. In addition, these results were compared with indices from conventional clinical exams to show the coincidence level. Methods: A 3D lung reconstruction method using patient chest radiography was applied to quantify lung-involvement volume using retrospective examinations of 50 patients who were diagnosed with pulmonary TB and treated with two different drugs schemes. Twenty-five patients were treated with Scheme I (rifampicin, isoniazid, and pyrazinamide), whereas twenty-five patients were treated with Scheme II (rifampicin, isoniazid, pyrazinamide, and ethambutol). Acute-phase reaction: Serum exams included C-reactive protein levels, erythrocyte sedimentation rate, and albumin levels. Pulmonary function was tested posttreatment. Results: We found strong agreement between lung involvement and serum indices pre- and posttreatment. Comparison of the functional severity degree with lung involvement based on 3D image quantification for both treatment schemes found a high correlation. Conclusions: The present 3D reconstruction method produced a satisfactory agreement with the acute-phase reaction, most notably a higher significance level with the C-reactive protein. We also found a quite reasonable coincidence between the 3D reconstruction method and the degree of functional lung impairment posttreatment. The performance of the quantification method was satisfactory when comparing the two treatment schemes. Thus, the 3D reconstruction quantification method may be useful tools for monitoring TB treatment. The association with serum indices are not only inexpensive and sensitive but also may be incorporated into the assessment of patients during TB treatment. (AU)

FAPESP's process: 15/01948-3 - Objective Quantification of Fibrosis/Inflammatory Process in Patients with Pulmonary Tuberculosis Using X-ray Chest Exams.
Grantee:Marcela de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate