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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of X-chromosome markers on reproductive traits of beef cattle

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Autor(es):
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Damasceno Carvalho, Caio Victor [1] ; Hermisdorff, Isis da Costa [2] ; Souza, Isadora Saraiva [2] ; Borges Junqueira, Gleb Strauss [2] ; Braga Magalhaes, Ana Fabricia [3] ; Simielli Fonseca, Larissa Fernanda [3] ; de Albuquerque, Lucia Galvao [3] ; Tonhati, Humberto [3] ; Carvalheiro, Roberto [3] ; Ferreira de Camargo, Gregorio Miguel [2] ; Costa, Raphael Bermal [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] UFOB, Barra, BA - Brazil
[2] Univ Fed Bahia UFBA, Escola Med Vet & Zootecnia, Salvador, BA - Brazil
[3] Univ Estadual Paulista, UNESP, Fac Ciencias Agr & Vet, Dept Zootecnia, Jaboticabal, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: LIVESTOCK SCIENCE; v. 220, p. 152-157, FEB 2019.
Citações Web of Science: 0
Resumo

Sex chromosomes are generally excluded from genomic analyses, although X chromosome is the second largest chromosome and harbors many genes. The objective of this study was to evaluate the effect of X chromosome by identifying its regions associated with reproductive traits in Nelore cows through a genome-wide association and by estimating its linkage disequilibrium. Phenotypic data of 76,845 and 76,700 animals were used for pregnancy at 16 months and age at first calving, respectively, as well as genotypic data of 1,999 females. Linkage disequilibrium was estimated for X chromosome and for autosomes 1 and 2, due to similar size of chromosomes. Single-step method was used for association analysis and some genes with known role in reproduction were reported for both traits, such as KLHL4 which is associated with development of the female reproductive system, and PCDH11X which is associated with the onset of primary ovarian insufficiency. Moreover, some genes were associated with both traits, indicating a pleiotropic effect. However, contribution of the windows in X-chromosome is very small when compared to autosomes: an unexpected fact. The results revealed higher linkage disequilibrium on the X chromosome (0.2248 +/- 0.17) compared to the other chromosomes (0.1965 +/- 0.14 and 0.1967 +/- 0.14 for autosomes 1 and 2, respectively), indicating low recombination rates. (AU)

Processo FAPESP: 09/16118-5 - Ferramentas genômicas no melhoramento genético de características de importância econômica direta em bovinos da raça Nelore
Beneficiário:Lucia Galvão de Albuquerque
Linha de fomento: Auxílio à Pesquisa - Temático