Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus

Texto completo
Autor(es):
Mostrar menos -
Batista, Mariana N. [1] ; Braga, Ana Claudia S. [1] ; Fernandes Campos, Guilherme Rodrigues [1] ; Souza, Marcos Michel [1] ; Adum de Matos, Renata Prandini [1] ; Lopes, Tairine Zara [1] ; Candido, Natalia Maria [1] ; Duarte Lima, Maria Leticia [1] ; Machado, Francielly Cristina [1] ; Queiroz de Andrade, Stephane Tereza [1] ; Bittar, Cintia [1] ; Nogueira, Mauricio L. [2] ; Carneiro, Bruno M. [1, 3] ; Mariutti, Ricardo B. [4] ; Arni, Raghuvir Krishnaswamy [4] ; Calmon, Marilia Freitas [1] ; Rahal, Paula [1]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, UNESP, Lab Genom Studies, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] FAMERP, Dept Doencas Infecciosas & Parasitarias, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Fed Mato Grosso, Inst Exact & Nat Sci, BR-78060900 Rondonopolis, MG - Brazil
[4] Sao Paulo State Univ, UNESP, Multiuser Ctr Biomol Innovat, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Viruses-Basel; v. 11, n. 1 JAN 2019.
Citações Web of Science: 1
Resumo

Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 mu M of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 mu M), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus. (AU)

Processo FAPESP: 14/22198-0 - Potencial terapêutico de fármacos flavonóidicos na infecção com o vírus da hepatite C
Beneficiário:Paula Rahal
Linha de fomento: Auxílio à Pesquisa - Regular