| Texto completo | |
| Autor(es): |
Pulido Diaz, Katya
[1]
;
Gondak, Rogerio
[2]
;
Martins, Leandro Liporoni
[3]
;
de Almeida, Oslei Paes
[4]
;
Leon, Jorge Esquiche
[5]
;
Mariano, Fernanda Viviane
[6]
;
Altemani, Albina
[6]
;
Vargas, Pablo Agustin
[4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Autonoma Baja California, Escuela Ciencias Salud UABC Valle Las Palmas, Mexicali, Baja California - Mexico
[2] Fed Univ Santa Catarina UFSC, Dept Pathol, Florianopolis, SC - Brazil
[3] Univ Sao Paulo, Sch Med HC FMUSP, Dept Pathol, Clin Hosp, Sao Paulo - Brazil
[4] State Univ Campinas FOP UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Oral Pathol, Piracicaba - Brazil
[5] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol Sect, Ribeirao Preto - Brazil
[6] State Univ Campinas UNICAMP, Dept Pathol, Fac Med, Campinas - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 48, n. 3, p. 232-238, MAR 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
Background Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA. (AU) | |
| Processo FAPESP: | 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica |
| Beneficiário: | Fernanda Viviane Mariano Brum Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 12/10781-7 - Análise da expressão de citoqueratinas, do padrão angiogênico, proliferativo e de conteúdo de DNA celular de tumores de glândulas salivares |
| Beneficiário: | Pablo Agustin Vargas |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |