Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma

Author(s)

Pulido Diaz, Katya ^[1] ; Gondak, Rogerio ^[2] ; Martins, Leandro Liporoni ^[3] ; de Almeida, Oslei Paes ^[4] ; Leon, Jorge Esquiche ^[5] ; Mariano, Fernanda Viviane ^[6] ; Altemani, Albina ^[6] ; Vargas, Pablo Agustin ^[4]

Affiliation

^[1] Univ Autonoma Baja California, Escuela Ciencias Salud UABC Valle Las Palmas, Mexicali, Baja California - Mexico

^[2] Fed Univ Santa Catarina UFSC, Dept Pathol, Florianopolis, SC - Brazil

^[3] Univ Sao Paulo, Sch Med HC FMUSP, Dept Pathol, Clin Hosp, Sao Paulo - Brazil

^[4] State Univ Campinas FOP UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Oral Pathol, Piracicaba - Brazil

^[5] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol Sect, Ribeirao Preto - Brazil

^[6] State Univ Campinas UNICAMP, Dept Pathol, Fac Med, Campinas - Brazil

• Document type: Journal article
• Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 48, n. 3, p. 232-238, MAR 2019.
• Web of Science Citations: 2

Abstract

Background Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA. (AU)

• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 12/10781-7 - Analysis of the expression of cytokeratins, angiogenic and proliferative patterns, and DNA content of salivary gland tumors
• Grantee: Pablo Agustin Vargas
• Support Opportunities: Regular Research Grants