Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

Texto completo
Autor(es):
Rahmani, Saher [1] ; Bouchmella, Karim [2, 3] ; Budimir, Jelena [1] ; Raehm, Laurence [1] ; Cardoso, Mateus Borba [2, 3] ; Trens, Philippe [1] ; Durand, Jean-Olivier [1] ; Charnay, Clarence [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Montpellier, Inst Charles Gerhardt Montpellier, CNRS, ENSCM, UMR 5253, Cc 1701, Pl Eugene Bataillon, F-34095 Montpellier 05 - France
[2] CNPEM, Lab Nacl Luz Sincrotron, BR-13083970 Campinas, SP - Brazil
[3] CNPEM, LNNano, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ACS OMEGA; v. 4, n. 1, p. 1479-1486, JAN 2019.
Citações Web of Science: 0
Resumo

The synthesis of hollow organosilica nanoparticles is described from bis triethoxysilylpropyldisulfide and bis(trimethoxylsilylpropyl) methylamine. The nanoparticles were monodisperse with a mean diameter of 90 nm, and the adsorption-desorption properties of these nanoparticles were investigated with nitrogen at 77 K, n-hexane, and water. The nanoparticles were nonporous at 77 K as shown by N-2 sorption analyses. n-Hexane interacted reversibly through physisorption with the nanoparticles, whereas water showed a strong nonreversible interaction, probably because of chemisorption with nitrogen atom sites. Amoxicillin antibiotic was loaded with these nanoparticles and the loading capacity was 30%. Ag+ ions were also adsorbed with amoxicillin, and the multifunctional nanoparticles were efficient in inhibiting bacterial growth with a synergy between the antibiotic delivery and Ag+ release. (AU)

Processo FAPESP: 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas
Beneficiário:Watson Loh
Modalidade de apoio: Auxílio à Pesquisa - Temático