Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

Author(s)

Rahmani, Saher ^[1] ; Bouchmella, Karim ^{[2, 3]} ; Budimir, Jelena ^[1] ; Raehm, Laurence ^[1] ; Cardoso, Mateus Borba ^{[2, 3]} ; Trens, Philippe ^[1] ; Durand, Jean-Olivier ^[1] ; Charnay, Clarence ^[1]

Affiliation

^[1] Univ Montpellier, Inst Charles Gerhardt Montpellier, CNRS, ENSCM, UMR 5253, Cc 1701, Pl Eugene Bataillon, F-34095 Montpellier 05 - France

^[2] CNPEM, Lab Nacl Luz Sincrotron, BR-13083970 Campinas, SP - Brazil

^[3] CNPEM, LNNano, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: ACS OMEGA; v. 4, n. 1, p. 1479-1486, JAN 2019.
• Web of Science Citations: 0

Abstract

The synthesis of hollow organosilica nanoparticles is described from bis triethoxysilylpropyldisulfide and bis(trimethoxylsilylpropyl) methylamine. The nanoparticles were monodisperse with a mean diameter of 90 nm, and the adsorption-desorption properties of these nanoparticles were investigated with nitrogen at 77 K, n-hexane, and water. The nanoparticles were nonporous at 77 K as shown by N-2 sorption analyses. n-Hexane interacted reversibly through physisorption with the nanoparticles, whereas water showed a strong nonreversible interaction, probably because of chemisorption with nitrogen atom sites. Amoxicillin antibiotic was loaded with these nanoparticles and the loading capacity was 30%. Ag+ ions were also adsorbed with amoxicillin, and the multifunctional nanoparticles were efficient in inhibiting bacterial growth with a synergy between the antibiotic delivery and Ag+ release. (AU)

• FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants